Pharmacokinetics and In Vitro Blood-Brain Barrier Screening of the Plant-Derived Alkaloid Tryptanthrin
E.A. Jähne, D.E. Eigenmann, Ch. Sampath, V. Butterweck, M. Culot, R. Cecchelli, F. Gosselet, F.R. Walter, M.A. Deli, M. Smieško, M. Hamburger, M. Oufir
Planta Med. 82, 1021 (2016).

Differences in the molecular structure of the blood-brain barrier in the cerebral cortex and white matter: an in silico, in vitro and ex vivo study
Á. Nyúl-Tóth, M. Suciu, J. Molnár, C. Fazakas, J. Haskó, H. Herman, A.E. Farkas, J. Kaszaki, A. Hermenean, I. Wilhelm, I.A. Krizbai
Am. J. Physiol. 310, H1702 (2016).

In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs
D.E. Eigenmann, C. Dürig, E.A. Jähne, M. Smieško, M. Culot, F. Gosselet, R. Cecchelli, H.Ch.C. Helms, B. Brodin, L. Wimmer, M.D. Mihovilovic, M. Hamburger, M. Oufir
Eur. J. Pharm. Biopharm. 103, 118 (2016).

Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier
S.E. Storck, S. Meister, J. Nahrath, J.N. Meißner, N. Schubert, A. Di Spiezio, S. Baches, R.E. Vandenbroucke, Y. Bouter, I. Prikulis, C. Korth, S. Weggen, A. Heimann, M. Schwaninger, T.A. Bayer, C.U. Pietrzik
J. Clin. Invest. 126, 123 (2016).

ZOT-derived peptide and chitosan functionalized nanocarrier for oral delivery of protein drug
J.H. Lee, A. Sahu, W.I. Choi, J.Y. Lee, G. Tae
Biomaterials 103, 160 (2016).

β-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function
N. Ziegler, K. Awwad, B. Fisslthaler, M. Reis, K. Devraj, M. Corada, S.P. Minardi, E. Dejana, K.H. Plate, I. Fleming, S. Liebner
J. Neurosci. 36, 8921 (2016).

Validation of UHPLC–MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies
F. Moradi-Afrapoli, M. Oufir, F.R. Walter, M.A. Deli, M. Smiesko, V. Zabela, V. Butterweck, M. Hamburger
J. Pharm. Biomed. Anal. 128, 264 (2016).

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells
K. Göbel, S. Pankratz, Ch.-M. Asaridou, A.M. Herrmann, S. Bittner, M. Merker, T. Ruck, S. Glumm, F. Langhauser, P. Kraft, T.F. Krug, J. Breuer, M. Herold, C.C. Gross, D. Beckmann, A. Korb-Pap, M.K. Schuhmann, S. Kuerten, I. Mitroulis, C. Ruppert, M.W. Nolte, C. Panousis, L. Klotz, B. Kehrel, T. Korn, H.F. Langer, T. Pap, B. Nieswandt, H. Wiendl, T. Chavakis, Ch. Kleinschnitz, S.G. Meuth
Nat. Commun. 7, 11626 (2016).

Flurbiprofen-loaded Nanoparticles Can Cross a Primary Porcine In vitro Blood-brain Barrier Model to Reduce Amyloid-β42 Burden
J. Stab, I. Zlatev, B. Raudszus, S. Meister, C.U. Pietrzik, K. Langer, H. von Briesen, S. Wagner
J. Nanomed. Biother. Discovery 6, 1000140 (2016).

Thermo-responsive cell culture carriers based on poly(vinyl methyl ether)—the effect of biomolecular ligands to balance cell adhesion and stimulated detachment
J. Teichmann, M. Nitschke, D. Pette, M. Valtink, S. Gramm, F.V. Härtel, T. Noll, R.H.W. Funk, K. Engelmann, C. Werner
Sci. Technol. Adv. Mater. 16, 045003 (2016).

Transient receptor potential A1 channels regulate epithelial cell barriers formed by MDCK cells
S. Dembla, N. Hasan, A. Becker, A. Beck, S.E. Philipp
FEBS Lett. 590, 1509 (2016).

Plasmalemma Vesicle–Associated Protein Has a Key Role in Blood-Retinal Barrier Loss
J. Wisniewska-Kruk, A.-E. van der Wijk, H.A. van Veen, T.G.M.F. Gorgels, I.M.C. Vogels, D. Versteeg, C.J.F. Van Noorden, R.O. Schlingemann, I. Klaassen
Am. J. Pathol. 186, 1044 (2016).

Angiopoietin‑2‑induced blood–brain barrier compromise and increased stroke size are rescued by VE‑PTP‑dependent restoration of Tie2 signaling
S. Gurnik, K. Devraj, J. Macas, M. Yamaji, J. Starke, A. Scholz, K. Sommer, M. Di Tacchio, R. Vutukuri, H. Beck, M. Mittelbronn, C. Foerch, W. Pfeilschifter, S. Liebner, K.G. Peters, K.H. Plate, Y. Reiss
Acta Neuropathol. 131, 753 (2016).

Modeling immune functions of the mouse blood–cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier
I. Lazarevic, B. Engelhardt
Fluids Barriers CNS 13, 2 (2016).

Targeting of the kynurenic acid across the blood–brain barrier by core-shell nanoparticles
N. Varga, E. Csapó, Z. Majláth, I. Ilisz, I.A. Krizbai, I. Wilhelm, L. Knapp, J. Toldi, L. Vécsei, I. Dékány
Eur. J. Pharm. Sci. 86, 67 (2016).

Secretion of Alpha-Hemolysin by Escherichia coli Disrupts Tight Junctions in Ulcerative Colitis Patients
H.C. Mirsepasi-Lauridsen, Z. Du, C. Struve, G. Charbon, J. Karczewski, K.A. Krogfelt, A.M. Petersen, J.M. Wells
Clin. Transl. Gastroenterol. 7, e149 (2016).

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction
P.G. Sreekumar, K. Ishikawa, C.S., H.H. Mehta, J. Wan, K. Yen, P. Cohen, R. Kannan, D.R. Hinton
Invest. Ophthalmol. Visual Sci. 57, 1238 (2016).

The Effect of Capsaicin Derivatives on Tight-Junction Integrity and Permeability of Madin-Darby Canine Kidney Cells
M. Kaiser, S.Chalapala, C. Gorzelanny, R.S. Perali, F.M. Goycoolea
J. Pharm. Sci. 105, 630 (2016).

Human Alpha-Defensin HNP1 Increases HIV Traversal of the Epithelial Barrier: A Potential Role in STI-Mediated Enhancement of HIV Transmission
K. Valere, A. Rapista, E. Eugenin, W. Lu, T.L. Chang
Viral Immunol. 28, 609 (2016).

Validation of an immortalized human (hBMEC) in vitro blood-brain barrier model
D.E. Eigenmann, E.A. Jähne, M. Smieško, M. Hamburger, M. Oufir
Anal. Bioanal. Chem. 408, 2095 (2016).



Using white noise to gate organic transistors for dynamic monitoring of cultured cell layers
J. Rivnay, P. Leleux, A. Hama, M. Ramuz, M. Huerta, G.G. Malliaras, R.M. Owens
Sci. Rep. 5, 11613 (2015).

ANKS1B Interacts with the Cerebral Cavernous Malformation Protein-1 and Controls Endothelial Permeability but Not Sprouting Angiogenesis
S.E. Herberich, R. Klose, I. Moll, W.-J. Yang, J. Wüstehube-Lausch, A. Fischer
PLoS One 10, e0145304 (2015).

Claudin-4 binder C-CPE 194 enhances effects of anticanceragents on pancreatic cancer cell lines via a MAPK pathway
K. Tsuyoshi, K. Masuo, K. Daisuke, I. Tatsuya, K. Yasutoshi, I. Masafumi, K. Takayuki, K. Takumi, F. Tomohisa, S. Norimasa, H. Koichi, K. Takashi
Pharmacol. Res. Perspect. 3, e00196 (2015).

Non-Saccharomyces yeasts protect against epithelial cell barrier disruption induced by Salmonella enterica subsp. enterica serovar Typhimurium
I.M. Smith, A. Baker, N. Arneborg, L. Jespersen
Lett. Appl. Microbiol. 61, 491 (2015).

Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier
A. Bernd, M. Ott, H. Ishikawa, H. Schroten, C. Schwerk, G. Fricker
Pharm. Res. 32, 2973 (2015).

Expression of the ALS-causing variant hSOD1G93A leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood–spinal cord barrier model
S. Meister, S. Storck, E. Hameister, C. Behl, S. Weggen, A. Clement, C. Pietrzik
J. Cereb. Blood Flow Metab. 35, 1112 (2015).

Transport of treosulfan and temozolomide across an in-vitro blood-brain barrier model
U. Linz, M. Hupert, B. Santiago-Schübel, S. Wien, J. Stab, S. Wagner
Anticancer Drugs 26, 728 (2015).

Arsenic-containing hydrocarbons and arsenic-containing fatty acids: Transfer across and presystemic metabolism in the Caco-2 intestinal barrier model
S. Meyer, G. Raber, F. Ebert, M.S. Taleshi, K.A. Francesconi, T. Schwerdtle
Mol. Nutr. Food Res. 59, 2044 (2015).

Irsogladine Maleate Regulates Gap Junctional Intercellular Communication-Dependent Epithelial Barrier in Human Nasal Epithelial Cells
R. Miyata, K. Nomura, T. Kakuki, K. Takano, T. Kohno, T. Konno, N. Sawada, T. Himi, T. Kojima
J. Membr. Biol. 248, 327 (2015).

Thermo-responsive cell culture carriers based on poly(vinyl methyl ether)—the effect of biomolecular ligands to balance cell adhesion and stimulated detachment
J. Teichmann, M. Nitschke, D. Pette, M. Valtink, S. Gramm, F.V. Härtel, T. Noll, R.H.W. Funk, K. Engelmann, C. Werner
Sci. Technol. Adv. Mater. 16, 045003 (2015).

Endothelial-Mesenchymal Transition of Brain Endothelial Cells: Possible Role during Metastatic Extravasation
I.A. Krizbai, Á. Gasparics, P. Nagyoszi, C. Fazakas, J. Molnár, I. Wilhelm, R. Bencs, L. Rosivall, A. Sebe
PLoS One 10, e0123845 (2015).

The blood–cerebrospinal fluid barrier – first evidence for an active transport of organic mercury compounds out of the brain
H. Lohren, J. Bornhorst, H.J. Galla, T. Schwerdtle
Metallomics 7, 1420 (2015).

In Vitro Blood–Brain Barrier Models—An Overview of Established Models and New Microfluidic Approaches
A. Wolff, M. Antfolk, B. Brodin, M. Tenje
J. Pharm. Sci. 104, 2727 (2015).

Organic electrochemical transistors for cell-based impedance sensing
J. Rivnay, M. Ramuz, P. Leleux, A. Hama, M. Huerta, R.M. Owens
Appl. Phys. Lett. 106, 043301 (2015).

Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers
C. Staat, C. Coisne, S. Dabrowski, S.M. Stamatovic, A.V. Andjelkovic, H. Wolburg, B. Engelhardt, I.E. Blasig
Biomaterials 54, 9 (2015).

Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier
M. Abadier, J. Haghayegh Jahromi, L. Cardoso Alves, R. Boscacci, D. Vestweber, S. Barnum, U. Deutsch, B. Engelhardt, R. Lyck
Eur. J. Immunol. 45, 1043 (2015).

Chitosan encapsulation modulates the effect of capsaicin on the tight junctions of MDCK cells
M. Kaiser, S. Pereira, L. Pohl, S. Ketelhut, B. Kemper, C. Gorzelanny, H.J. Galla, B. M. Moerschbacher, F.M. Goycoolea
Sci. Rep. 5, 10048 (2015).

Dynamic Regulation of a Cell Adhesion Protein Complex Including CADM1 by Combinatorial Analysis of FRAP with Exponential Curve-Fitting
M. Sakurai-Yageta, T. Maruyama, T. Suzuki, K. Ichikawa, Y. Murakami
PLoS One 10, e0116637 (2015).

Live Faecalibacterium prausnitzii in an apical anaerobic model of the intestinal epithelial barrier
D. Ulluwishewa, R.C. Anderson, W. Young, W.C. McNabb, P. van Baarlen, P.J. Moughan, J.M. Wells, N.C. Roy
Cell Microbiol. 17, 226 (2015).

Nanotoxicity of poly(n-butylcyano-acrylate) nanoparticles at the blood–brain barrier, in human whole blood and in vivo
M. Kolter , M. Ott, C. Hauer, I. Reimold, G. Fricker
J. Control Release 197, 165 (2015).

Intestinal formation of trans-crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier
M. Lautenschläger, J. Sendker, S. Hüwel, H.J. Galla, S. Brandt, M. Düfer, K. Riehemann, A. Hensel
Phytomed. 22, 36 (2015).



The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro
S. Cramer, S. Tacke, J. Bornhorst, J. Klingauf, T. Schwerdtle, H.-J. Galla
J. Nanomed. Nanotechnol. 5, 225 (2014).

Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation
K. Ridder, S. Keller, M. Dams, A.-K. Rupp, J. Schlaudraff, D. Del Turco, J. Starmann, J. Macas, D. Karpova, K. Devraj, C. Depboylu, B. Landfried, B. Arnold, K.H. Plate, G. Höglinger, H. Sültmann, P. Altevogt, S. Momma
PLoS Biol. 12, e1001874 (2014).

Freeze-drying of HI-6-loaded recombinant human serum albumin nanoparticles for improved storage stability
M. Dadparvar, S. Wagner, S. Wien, F. Worek, H. von Briesen, J. Kreuter
Euro. J. Pharm. Biopharm. 88, 510 (2014).

Differential apicobasal VEGF signaling at vascular blood-neural barriers
N. Hudson, M.B. Powner, M.H. Sarker, T. Burgoyne, M. Campbell, Z.K. Ockrim, R. Martinelli, C.E. Futter, M.B. Grant, P.A. Fraser, D.T. Shima, J. Greenwood, P. Turowski
Dev. Cell. 30, 541 (2014).

Dietary Xylo-oligosaccharide stimulates intestinal bifidobacteria and lactobacilli but has limited effect on intestinal integrity in rats
E.G. Christensen, T.R. Licht, T.D. Leser, M.I. Bahl
BMC Res. Notes 7, 660 (2014).

Development and validation of a LC–MS/MS method for assessment of an anti-inflammatory indolinone derivative by in vitro blood–brain barrier models
E.A. Jähne, D.E. Eigenmann, M. Culot, R. Cecchelli, F.R. Walter, M.A. Deli, R. Tremmel, G. Fricker, M. Smiesko, M. Hamburger, M. Oufir
J. Pharm. Biomed. Anal. 98, 235 (2014).

Synthesis and Pharmacological Evaluation of 5-Pyrrolidinylquinoxalines as a Novel Class of Peripherally Restricted κ-Opioid Receptor Agonists
C. Bourgeois, E. Werfel, F. Galla, K. Lehmkuhl, H. Torres-Gómez, D. Schepmann, B. Kögel, T. Christoph, W. Straßburger, W. Englberger, M. Soeberdt, S. Hüwel, H.-J. Galla, B. Wünsch
J. Med. Chem. 57, 6845 (2014).

Lipocalin-2 deficiency attenuates neuroinflammation and brain injury after transient middle cerebral artery occlusion in mice
M. Jin, J.-H. Kim, E. Jang, Y.M. Lee, H.S. Han, D.K. Woo, D.H. Park, H. Kook, K. Suk
J. Cereb. Blood Flow Metab. 34, 1306 (2014).

The antimicrobial protein S100A7/psoriasin enhances theexpression of keratinocyte differentiation markers andstrengthens the skin’s tight junction barrier
F. Hattori, C. Kiatsurayanon, K. Okumura, H. Ogawa, S. Ikeda, K. Okamoto, F. Niyonsaba
Br. J. Dermatol. 171, 742 (2014).

The Human Cathelicidin LL-37 Host Defense Peptide Upregulates Tight Junction-Related Proteins and Increases Human Epidermal Keratinocyte Barrier Function
T: Akiyama, F: Niyonsaba, Ch. Kiatsurayanon, T.T. Nguyen, H. Ushio, T. Fujimura, T. Ueno, K. Okumura, H. Ogawa, S. Ikeda
J. Innate Immun. 6, 739 (2014).

The M1 Protein of Streptococcus pyogenes Triggers an Innate Uptake Mechanism into Polarized Human Endothelial Cells
A. Ochel, M. Rohde, G.S. Chhatwal, S.R. Talay
J. Innate Immun. 6, 585 (2014).

PACAP Enhances Barrier Properties of Cerebral Microvessels
I. Wilhelm, C. Fazakas, A. Tamás, G. Tóth, D. Regl, I.A. Krizbai
J. Mol. Neurosci. 54, 469 (2014).

Dynamic Monitoring of Salmonella typhimurium Infection of Polarized Epithelia Using Organic Transistors
S.A. Tria, M. Ramuz, M. Huerta, P. Leleux, J. Rivnay, L.H. Jimison, A. Hama, G.G. Mall
Adv. Healthcare Mater. 3, 1053 (2014).

Host Defense (Antimicrobial) Peptide, Human β-Defensin-3, Improves the Function of the Epithelial Tight-Junction Barrier in Human Keratinocytes
C. Kiatsurayanon, F. Niyonsaba, R. Smithrithee, T. Akiyama, H. Ushio, M. Hara, K. Okumura, S. Ikeda, H. Ogawa
Invest. Dermatol. 134, 2163 (2014).

Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice
S.W. Park, J.H. Kim, I Mook-Jung, K.-W. Kim, W.J. Park, K.H. Park, J.H. Kim
Neurobiol Aging. 35, 2013 (2014).

Comprehensive Cysteine-Scanning Mutagenesis Reveals Claudin-2 Pore-Lining Residues with Different Intrapore Locations
J. Li, M. Zhuo, L. Pei, M. Rajagopa, A.S.L. Yu
J. Biol. Chem. 289, 6475 (2014).

The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers
M.K. Nøhra, S.H. Hansena, B. Brodin, R. Holm, C.U. Nielsen
Euro. J. Pharm. Sci. 51, 1 (2014).

Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells.
K. Nomura, K. Obata, T. Keira, R. Miyata, S. Hirakawa, K. Takano, T. Kohno, N. Sawada, T. Himi, T. Kojima
Respir. Res. 15, 21 (2014).

In Vitro Models of the Blood–Brain Barrier
C.J. Czupalla, S. Liebner, K. Devraj
Cerebral Angiogenesis Method Molec. Biol. 1135, 415 (2014).

Increased Efflux of Amyloid-β Peptides through the Blood-Brain Barrier by Muscarinic Acetylcholine Receptor Inhibition Reduces Pathological Phenotypes in Mouse Models of Brain Amyloidosis
P. Paganetti, K. Antoniello, K. Devraj, N. Toni, D. Kieran, R. Madani, M. Pihlgren, O. Adolfsson, W. Froestl, A. Schrattenholz, S. Liebner, D. Havas, M. Windisch, J.R. Cirrito, A. Pfeifer, A. Muhs
J. Alzheimer's Disease 38, 767 (2014).

What Is the Mechanism Behind Increased Permeation Rate of a Poorly Soluble Drug from Aqueous Dispersions of an Amorphous Solid Dispersion?
K.J. Frank, U. Westedt, K.M. Rosenblatt, P. Hölig, J. Rosenberg, M. Mägerlein, G. Fricker, M. Brandl
J. Pharm. Sci. 103, 1779 (2014).



Vectorial secretion of interleukin-8 mediates autocrine signalling in intestinal epithelial cells via apically located CXCR1
O. Rossi , J. Karczewski, E.H. Stolte, R.J.M. Brummer, M.A. van Nieuwenhoven, M. Meijerink, J.R.J. van Neerven, S.C.D. van Ijzendoorn, P. van Baarlen, J.M. Wells
BMC Res. Notes 6, 431 (2013).

Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier In Vitro
R. Paolinelli, M. Corada, L. Ferrarini, K. Devraj, C. Artus, C.J. Czupalla, N. Rudini, L. Maddaluno, E. Papa, B. Engelhardt, P.O. Couraud, S. Liebner, E. Dejana
PLoS One 8, e70233 (2013).

Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS
S. Bittner, T. Ruck, M.K. Schuhmann, A.M. Herrmann, H. Moha ou Maati, N. Bobak, K. Göbel, F. Langhauser, D. Stegner, P. Ehling, M. Borsotto, H.-C. Pape, B. Nieswandt, C. Kleinschnitz, C. Heurteaux, H.-J. Galla, T. Budde, H. Wiendl, S.G. Meuth
Nat. Med. 19, 1161 (2013).

In vitro intestinal bioavailability of arsenosugar metabolites and presystemic metabolism of thio-dimethylarsinic acid in Caco-2 cells
L. Leffers, C.A. Wehe, S. Hüwel, M. Bartel, F. Ebert, M.S. Taleshi, H.-J. Galla, U. Karst, K.A. Francesconie, T. Schwerdtle
Metallomics 5, 1031 (2013).

Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood-brain barrier model for drug permeability studies
D.E. Eigenmann, G. Xue, K.S. Kim KS, A.V. Moses, M. Hamburger, M. Oufir
Fluids Barriers CNS 10, 33 (2013).

Transepithelial permeability studies of flavan-3-ol-C-glucosides and procyanidin dimers and trimers across the Caco-2 cell monolayer
S. Hemmersbach, S.S. Brauer, S. Hüwel, H.J. Galla, H.U. Humpf
J. Agric. Food Chem. 61, 7932 (2013).

The cytokine response of U937-derived macrophages infected through antibody dependent enhancent of dengue virus disrupts cell apical junctional complexes and increase vascular permeability
H. Puerta-Guardo, A. Raya Sandino, L. González-Mariscal, V.H. Rosales, J. Ayala-Dávila, B. Chávez-Mungía, D. Martínez-Fong, F. Medina, J.E. Ludert, R. María del Angel
J. Virol. 87, 7486 (2013).

Acetaminophen Changes Intestinal Epithelial Cell Membrane Properties, Subsequently Affecting Absorption Processes
C. Schäfer, K.R. Schröder, O. Höglinger, S. Tollabimazraehno, M.R. Lornejad-Schäfer
Cell Physiol. Biochem. 32, 431 (2013).

Validation of the organic electrochemical transistor for in vitro toxicology
S. Tria, L.H. Jimison, A. Hama, M. Bongo, R.M. Owens
Biochim. Biophys. Acta 1830, 4381 (2013).

In vitro toxicological characterization of two arsenosugars and their metabolites
L. Leffers, F. Ebert, M.S. Taleshi, K.A. Francesconi, T. Schwerdtle
Mol. Nutr. Food Res. 57, 1270 (2013).

Expression of Shiga toxin 2e glycosphingolipid receptors of primary porcine brain endothelial cells and toxin-mediated breakdown of the blood-brain barrier
I. Meisen, R. Rosenbrück, H.J. Galla, S. Hüwel, I.U. Kouzel, M. Mormann, H. Karch, J. Müthing
Glycobiol. 23, 745 (2013).

Impedance-based cell monitoring: barrier properties and beyond
K. Benson, S. Cramer, H.J. Galla
Fluids Barriers CNS 10, 5 (2013).

Influence of T-2 and HT-2 Toxin on the Blood-Brain Barrier In Vitro: New Experimental Hints for Neurotoxic Effects.
M. Weidner, S. Hüwel, F. Ebert, T. Schwerdtle, H.J. Galla, H.U. Humpf
PLoS ONE 8, e60484 (2013).

Constitutive androstane receptor upregulates Abcb1 and Abcg2 at the blood–brain barrier after CITCO activation
J. Lemmen, I.E.P. Tozakidis, P. Bele, H.J. Galla
Brain Res. 1501, 68 (2013).

Sensing of EGTA Mediated Barrier Tissue Disruption with an Organic Transistor
S. Tria, L.H. Jimison, A. Hama, M. Bongo, R.M. Owens
Biosen. 3, 44 (2013).

Pregnane X receptor upregulates ABC-transporter Abcg2 and Abcb1 at the blood-brain barrier
J. Lemmen, I.E.P. Tozakidis, H.J. Galla
Brain Res. 1491, 1 (2013).



Amorphous solid dispersion enhances permeation of poorly soluble ABT-102: True supersaturation vs. apparent solubility enhancement
K.J. Franka, K.M. Rosenblatt, U. Westedt, P. Hölig, J. Rosenberg, M. Mägerlein, G. Fricker, M. Brandl
Int. J. Pharm. 437, 288 (2012).

Impact of manganese on and transfer across the blood-brain and blood-CSF barrier in vitro
J. Bornhorst, C.A. Wehe, S. Hüwel, U. Karst, H.J. Galla, T. Schwerdtle
J. Biol. Chem. 287, 17140 (2012).

Impact of FaSSIF on the solubility and dissolution-/permeation rate of a poorly water-soluble compound
K. J. Frank, U. Westedt, K. M. Rosenblatt, P. Hölig, J. Rosenberg,
M. Mägerlein, M. Brandl, G. Fricker
Euro. J. Pharm. Sci. 47, 16 (2012).

Cellular Interactions of a Water-Soluble Supramolecular Polymer Complex of Carbon Nanotubes with Human Epithelial Colorectal Adenocarcinoma Cells
Y. Lee, K. E. Geckeler
Macro. Biosci. 12, 1060 (2012).

Receptor-Mediated Delivery of Magnetic Nanoparticles across the Blood–Brain Barrier
R. Qiao, Q. Jia, S. Hüwel, R. Xia, T. Liu, F. Gao, H.J. Galla, M. Gao
ACS Nano 6, 3304 (2012).

Inhibitory effect of phospholipids on P-glycoprotein: Cellular studies in Caco-2, MDCKII mdr1 and MDCKII wildtype cells and P-gp ATPase activity measurements
S. Simon, R. Schubert
Biochim. Biophys. Acta 1821, 1211 (2012).

Streptococcus pneumoniae induces exocytosis of Weibel-Palade bodies in pulmonary endothelial cells
M. Lüttge, M. Fulde, S.R. Talay, A. Nerlich, M. Rohde, K.T. Preissner, S. Hammerschmidt, M. Steinert, T.J. Mitchell, G.S. Chhatwal, S. Bergmann
Cell. Microbiol. 14, 210 (2012).

aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation
S. Iden, S. Misselwitz, S.S.D. Peddibhotla, H. Tuncay, D. Rehder, V. Gerke, H. Robenek, A. Suzuki, K. Ebnet
J. Cell. Biol. 196, 623 (2012).

Permeability of ergot alkaloids across the blood–brain barrier in vitro and influence on the barrier integrity
D. Mulac, S. Hüwel, H.J. Galla, H.U. Humpf
Mol. Nutr. Food Res. 56, 475 (2012).

Mechanism of Clostridium perfringens Enterotoxin Interaction with Claudin-3/-4 Protein Suggests Structural Modifications of the Toxin to Target Specific Claudins
A. Veshnyakova, J. Piontek, J. Protze, N. Waziri, I. Heise, G. Krause
J. Biol. Chem. 287, 1698 (2012).

Identification of specific miRNAs targeting proteins of the apical junctional complex that simulate the probiotic effect of E. coli Nissle 1917 on T84 epithelial cells
K. Veltman, S. Hummel, C. Cichon, U. Sonnenborn, M.A. Schmidt
Int. J. Biochem. Cell Biol. 44, 341 (2012).

Preparation and properties of nanoscale containers for biomedical application in drug delivery: preliminary studies with kynurenic acid
V. Hornok, T. Bujdosó, J. Toldi, K. Nagy, I. Demeter, C. Fazakas, I. Krizbai, L. Vécsei, I. Dékány
J. Neural. Transm. 119, 115 (2012).

Differential Targeting of the E-Cadherin/β-Catenin Complex by Gram-positive Probiotic Lactobacilli Improves Epithelial Barrier Function
S. Hummel, K. Veltman, C. Cichon, U. Sonnenborn, M.A. Schmidt
Appl. Environ. Microbiol. 78, 1140 (2012).



Effect of the non-ionic surfactant Poloxamer 188 on passive permeability of poorly soluble drugs across Caco-2 cell monolayers
S.M. Fischer, M. Brandl, G. Fricker
J. Pharm. Biopharm. 79, 416 (2011).

HI 6 human serum albumin nanoparticles - Development and transport over an in vitro blood-brain barrier model
M. Dadparvara, S. Wagner, S. Wien, J. Kufleitner, F. Worek, H. von Briesen, J. Kreutera
Tox. Lett. 206, 60 (2011).

Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo
M. Schnoor, F.P.L. Lai, A. Zarbock, R. Kläver, C. Polaschegg, D. Schulte, H.A. Weich, J.M. Oelkers, K. Rottner, D. Vestweber
J. Exp. Med. 208, 1721 (2011).

Transmigration of Melanoma Cells through the Blood-Brain Barrier: Role of Endothelial Tight Junctions and Melanoma-Released Serine Proteases
C. Fazakas, I. Wilhelm, P. Nagyöszi, A.E. Farkas, J. Hasko, J. Molnar, H. Bauer, H.C. Bauer, F. Ayaydin, N.T.K. Dung, L. Siklos, I.A. Krizbai
PLoS ONE 6, e20758 (2011) .

The impact of pericytes on the blood–brain barrier integrity depends critically on the pericyte differentiation stage
G. Thanabalasundaram, J. Schneidewind, C. Pieper, H.J. Galla
Int. J. Biochem. Cell Biol. 43, 1284 (2011) .

Transport of Arylsulfatase A across the Blood-Brain Barrier in Vitro
F. Matthes, P. Wölte, A. Böckenhoff, S. Hüwel, M. Schulz, P. Hyden, J. Fogh, V. Gieselmann, H.J. Galla, U.Matzner
J. Biol. Chem. 286, 17487 (2011).

In vitro models of the blood-brain barrier
I. Wilhelm, C. Fazakas, I. A. Krizbai
Acta Neurobiol. Exp. 71, 113 (2011).

Transport of Poly(n-butylcyano-acrylate) nanoparticles across the blood–brain barrier in vitro and their influence on barrier integrity
R. Rempe, S. Cramer, H.J. Galla
Biochem. Biophys. Res. Commun. 406, 64 (2011).

Interactions of the prion peptide (PrP 106–126) with brain capillary endothelial cells: coordinated cell killing and remodeling of intercellular junctions
I. Cooper, K.C.-K. Malina, A. Cagnotto, G. Bazzoni, M. Salmona, V.I. Teichberg
J. Neurochem. 116, 467 (2011).

Neutrophils cross the BBB primarily on transcellular pathways: An in vitro study
M. von Wedel-Parlow, S. Schrot, J. Lemmen, L. Treeratanapiboon, J. Wegener, H.J. Galla
Brain Res. 1367, 62 (2011).



Epithelial Barrier Resistance is Increased by the Divalent Cation Zinc in Cultured MDCKII Epithelial Monolayers
G. Carr, J.A. Wright, N.L. Simmons
J. Membr. Biol. 237, 115 (2010).

Metalloproteinase mediated occludin cleavage in the cerebral microcapillary endothelium under pathological conditions
M. Lischper, S. Beuck, G. Thanabalasundaram, C. Pieper, H.J. Galla
Brain Res. 1326, 114 (2010).

Nanoparticulate Transport of Oximes over an In Vitro Blood-Brain Barrier Model
S. Wagner, J. Kufleitner, A. Zensi, M. Dadparvar, S. Wien, J. Bungert, T. Vogel, F. Worek, J. Kreuter, H. von Briesen
PLoS ONE 5, e14213 (2010).

Functionalized gold nanoparticles: a detailed in vivo multimodal microscopic brain distribution study
F. Sousa, S. Mandal,C. Garrovo, A. Astolfo, A. Bonifacio, D. Latawiec,R.H. Menk, F. Arfelli, S. Hüwel, G. Legname, H.J. Galla, S. Krol
Nanoscale 2, 2826 (2010).

In vitro evaluation of liposomes containing bio-enhancers for the oral delivery of macromolecules
J. Parmentier, F.J. Hartmann, G. Fricker
Euro. J. Pharm. Biopharm. 76, 394 (2010).

Characterization of immortalized choroid plexus epithelial cell lines for studies of transport processes across the blood-cerebrospinal fluid barrier
J. Kläs, H. Wolburg, T. Terasaki, G. Fricker, V. Reichel
Cerebrospinal Fluid Res. 7, 11 (2010).

Regulation of the blood-brain barrier integrity by pericytes via matrix metalloproteinases mediated activation of vascular endothelial growth factor in vitro
G. Thanabalasundaram, C. Pieper, M. Lischper, H.J. Galla
Brain Res. 1347, 1 (2010).

Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier
J. Karczewski, F.J. Troost, I. Konings, J. Dekker, M. Kleerebezem, R.-J.M. Brummer, J.M. Wells
Am. J. Physiol. Gastrointest. Liver Physiol. 298, G851 (2010).

In vitro-Testverfahren zur Toxikologie von Nanomaterialien
A. Kroll, D. Hahn, J. Schnekenburger
BIOspectrum 16, 48 (2010).



Regulation of major efflux transporters under inflammatory conditions at the blood brain barrier in vitro
M. von Wedel-Parlow, P. Wölte, H.J. Galla
J. Neurochem. 111, 111 (2009).

Closing the gap between the in-vivo and in-vitro blood–brain barrier tightness
K.C.-K. Malina, I. Cooper, V.I. Teichberg
Brain Res. 1284, 12 (2009).

Control of the blood-brain barrier by glucocorticoids and the cells of the neurovascular unit
S. Kröll, J. El-Gindi, G. Thanabalasundaram, P. Panpumthong, S. Schrot, C. Hartmann, H.J. Galla
Ann. N.Y. Acad. Sci. 1165, 228 (2009).