cellZscope systems
are the ideal tools for studying epithelial or endothelial cells in vitro.

cellZscope systems allow automated, long-term monitoring experiments with up to 96 different cell cultures simultaneously. The transepithelial/transendothelial electrical resistance (TEER) and optionally the capacitance (Ccl) of various types of barrier-forming cells cultured on permeable membranes can be analyzed in real-time. The cellZscope is easy to operate and has a broad range of possible applications.


Impedance Based Cell Monitoring – From Short-Term Tight Junction (TJ) Dynamics To Long-Term Layer Formation

MDCKII cells treated with EGTA in the cellZscope

Topics:

  • Influence of different concentrations of EGTA on the tight junction network (TEER) of Madin-Darby canine kidney (MDCK) cells.
  • Control of layer formation and differentiation of Caco-2 cells over several weeks.

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Monitoring Barrier Properties of MDCK Cell Layers During Depletion of Cell Cholesterol by MBCD

MDCK cell layer (barrier) treated with MBCD in the cellZscope

Topics:

  • Monitoring of the junction formation of Madin-Darby canine kidney (MDCK) cells.
  • Dose dependent response of barrier (TEER) and cell layer capacitance Ccl on MBCD.

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Studying Compound Mediated Effects on Cultured Primary Endothelial and Epithelial Cells

cellZscope - Influence of serum and hydrocortisone on cultured primary endothelial and epithelial cells

Topics:

  • Barrier of cultured primary endothelial cells derived from porcine brain microvessels dependent on the presence of hydrocortisone.
  • Influence of serum on the cell layer morphology of cultured primary epithelial cells derived from porcine choroid plexus.

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Measuring TEER — A Comparative Study: cellZscope vs. Handheld Devices With “Chopstick” Electrodes

cellZscope - Advantages of an automated TEER measurement compared to hand-held devices

Topics:

  • Automated and continious measurement of the TEER with the cellZscope compared to taking single measuring points with a hand-held device.
  • Advantages of a non-interfering measurement in the incubator compared to disruptive influences during manual handling.

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