peer-reviewed publications:


Reversing Aß Fibrillation and Inhibiting Aß Primary Neuronal Cell Toxicity Using Amphiphilic Polyphenylene Dendrons
S. Xiang, J. Wagner, T. Lückerath, K. Müllen, D.Y.W. Ng, J. Hedrich, T. Weil
Adv. Healthc. Mater. 11, e2101854 (2022).
→ doi: 10.1002/adhm.202101854

A Biomicrofluidic Screening Platform for Dysfunctional Endothelium-Targeted Nanoparticles and Therapeutics
S. Bazban-Shotorbani, F. Gavins, K. Kant, M. Dufva, N. Kamaly
Adv. NanoBiomed Res. 2, 2100092 (2022).
→ doi: 10.1002/anbr.202100092

Serially passaged, conditionally reprogrammed nasal epithelial cells as a model to study epithelial functions and SARS-CoV-2 infection
H. Schmidt, L. Gutjahr, A. Sauter, F. Zech, R. Nchioua, S. Stenger, M. Frick, F. Kirchhoff, P. Dietl, O.H. Wittekindt
Am. J. Physiol. tba, tba (2022).
→ doi: 10.1152/ajpcell.00363.2021

Intestinal Epithelial AMPK Deficiency Causes Delayed Colonic Epithelial Repair in DSS-Induced Colitis
S. Olivier, H. Diounou, C. Pochard, L. Frechin, E. Durieu, M. Foretz, M. Neunlist, M. Rolli-Derkinderen, B. Viollet
Cells 11, 590 (2022).
→ doi: 10.3390/cells11040590

Hexafluoroisopropyl Carbamates as Selective MAGL and Dual MAGL/FAAH Inhibitors: Biochemical and Physicochemical Properties
M. Barth, S. Rudolph, J. Kampschulze, I. Meyer zu Vilsendorf, W. Hanekamp, D. Mulac, K. Langer, M. Lehr
ChemMedChem tba, e202100 (2022).
→ doi: 10.1002/cmdc.202100757

GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression
V. Königs, S. Pierre, M. Schicht, J. Welss, L. Hahnefeld, V. Rimola, E. Lütjen-Drecoll, G. Geisslinger, K. Scholich
Diabetes tba, db210711 (2022).
→ doi: 10.2337/db21-0711

Re-evaluation of the hCMEC/D3 based in vitro BBB model for ABC transporter studies
V. Balzer, P. Poc, E. Puris, S. Martin, M. Aliasgari, S. Aurio, G. Fricker
Eur. J. Pharm. Biopharm. 173, 12 (2022).
→ doi: 10.1016/j.ejpb.2022.02.017

Highly cationic cell-penetrating peptides affect the barrier integrity and facilitates mannitol permeation in a human stem cell-based blood-brain barrier model
P. Frøslev, H. Franzyk, B. Ozgür, B. Brodin, M. Kristensen
Eur. J. Pharm. Sci. 168, 106054 (2022).
→ doi: 10.1016/j.ejps.2021.106054

The pore-forming subunit C2IIa of the binary clostridium botulinum C2 toxin reduces the chemotactic translocation of human polymorphonuclear leukocytes
J. Eisele, S. Schreiner, J. Borho, S. Fischer, S. Heber, S. Endres, M. Fellermann, L. Wohlgemuth, M. Huber-Lang, G. Fois, M. Fauler, M. Frick, H. Barth
Front. Pharmacol. 13, 810611 (2022).
→ doi: 10.3389/fphar.2022.810611

T-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model
K. El-Hindi, S. Brachtendorf, J.C. Hartel, S. Oertel, K. Birod, N. Merz, S. Trautmann, D. Thomas, A. Weigert, T.J. Schäufele, K. Scholich, S. Schiffmann, T. Ulshöfer, O. Utermöhlen, S. Grösch
Int. J. Mol. Sci. 23, 1866 (2022).
→ doi: 10.3390/ijms23031866

Intestinal Absorption and Metabolism of the Tomato Imidazole Alkaloids N-Caprylhistamine-ß-glucoside and N-Caprylhistamine
M. Kasimir, M. Hahn, I. Westkamp, A. Karentzopoulos, M. Behrens, Y. Hövelmann, H.-U. Humpf
J. Agric. Food Chem. 70, 1526 (2022).
→ doi: 10.1021/acs.jafc.1c08047

Exploring lipophilic compounds that induce BDNF secretion in astrocytes beyond the BBB using a new multi-cultured human in vitro BBB model
M. Fujisawa, Y. Takeshita, S. Fujikawa, K. Matsuo, M. Okamoto, M. Tamada, F. Shimizu, Y. Sano, M. Koga, T. Kanda
J. Neuroimmunol. 362, 577783 (2022).
→ doi: 10.1016/j.jneuroim.2021.577783

Endothelial Sphingosine-1-Phosphate Receptor 4 Regulates Blood-Brain Barrier Permeability and Promotes a Homeostatic Endothelial Phenotype
L. Hansen, N. Lohfink, R. Vutukuri, R.-I. Kestner, S. Trautmann, M. Hecht, P.V. Wagner, D. Spitzer, M.I. Khel, J. Macas, N. Ferreirós, R. Gurke, S. Günther, W. Pfeilschifter, K. Devraj
J. Neurosci. 42, 1908 (2022).
→ doi: 10.1523/JNEUROSCI.0188-21.2021

TRPV4 Stimulation Level Regulates Ca2+-Dependent Control of Human Corneal Endothelial Cell Viability and Survival
J. Donau, H. Luo, I. Virta, A. Skupin, M. Pushina, J. Loeffler, F.V. Haertel, A. Das, T. Kurth, M. Gerlach, D. Lindemann, P.S. Reinach, S. Mergler 3, M. Valtink
Membranes 12, 281 (2022).
→ doi: 10.3390/membranes12030281

In Vitro–In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier
L. Kovar, L. Wien, D. Selzer, Y. Kohl, R. Bals, T. Lehr
Pharmaceuticals 15, 250 (2022).
→ doi: 10.3390/ph15020250



Effect of Nanoparticle Biophysicochemical Properties on Binding and Transport across Cardiovascular Endothelial Dysfunction Models
S. Bazban-Shotorbani, H.A. Khare, J. Kajtez, S. Basak, J.H.Lee, N. Kamaly
ACS Appl. Nano Mater. 4, 4077 (2021).
→ doi: 10.1021/acsanm.1c00397

Small Extracellular Vesicles Propagate the Inflammatory Response After Trauma
T. Seibold, J. Schönfelder, F. Weeber, A. Lechel, M. Armacki, M. Waldenmaier, C. Wille, A. Palmer, R. Halbgebauer, E. Karasu, M. Huber-Lang, M. Kalbitz, P. Radermacher, S. Paschke, T. Seufferlein, T. Eiseler
Adv. Sci. 8, 2102381 (2021).
→ doi: 10.1002/advs.202102381

Genomic Stability and Phenotypic Characteristics of Industrially Produced Lacticaseibacillus rhamnosus GG in a Yogurt Matrix
M.S. Strickertsson, Y. Hui, D.S. Nielsen, N.I. Vera-Jiménez, J. Olsen, A. Sandelin, A. Wichmann
Appl. Environ. Microbiol. 87, e01575-21 (2021).
→ doi: 10.1128/AEM.01575-21

Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation of CLDN5 (claudin 5)
Z. Yang, P. Lin, B. Chen, X. Zhang, W. Xiao, S. Wu, Ch. Huang, D. Feng, W. Zhang, J. Zhang
Autophagy 17, 3048 (2021).
→ doi: 10.1080/15548627.2020.1851897

Potential neurotoxicity of titanium implants: Prospective, in-vivo and in-vitro study
S. Shelly, S.L. Zaltsman, O. Ben-Gal, A. Dayan, I. Ganmore, C. Shemesh, D. Atrakchi, S. Garra, O. Ravid, D. Rand, H. Israelov, T. Alon, G. Lichtenstein, S. Sharabi, D. Last, F. Gosselet, V. Rosen, G. Burstein, A. Friedlander, R. Harel, G. Vogel, M.S. Beeri, Y. Mardor, Y. Lampl, G. Fleminger, I. Cooper
Biomaterials 276, 121239 (2021).
→ doi: 10.1016/j.biomaterials.2021.121039

Investigating VCAM-1 Targeted Nanoparticles and Annexin A1 Therapy using Dysfunctional-endothelium-on-a-chip
S. Bazban-Shotorbani, F. Gavins, M. Dufva, N. Kamaly
bioRxiv tba, tba (2021).
→ doi: 10.1101/2021.05.09.443301

IL-6 blockade suppresses the blood-brain barrier disorder, leading to prevention of onset of NMOSD
Y. Takeshita, S. Fujikawa, K. Serizawa, M. Fujisawa, K. Matsuo, J. Nemoto, F. Shimizu, Y. Sano, H. Tomizawa-Shinohara, S. Miyake, R.M. Ransohoff, T. Kanda
bioRxiv tba, tba (2021).
→ doi: 10.1101/2021.01.28.428564

Comparison of Leading Biosensor Technologies to Detect Changes in Human Endothelial Barrier Properties in Response to Pro-Inflammatory TNFa and IL1ß in Real-Time
J.J.W. Hucklesby, A. Anchan, S.J. O'Carroll, Ch.P. Unsworth, E.S. Graham, C.E. Angel
Biosensors 11, 159 (2021).
→ doi: 10.3390/bios11050159

Establishment and Characterization of a Novel Gill Cell Line, LG-1, from Atlantic Lumpfish (Cyclopterus lumpus L.)
H. Sindre, M.C. Gjessing, J.H. Fosse, L.C. Hermansen, I. Böckerman, M.M. Amundsen, M.K. Dahle, A. Solhaug
Cells 10, 2442 (2021).
→ doi: 10.3390/cells10092442

Estradiol Inhibits Human Brain Vascular Pericyte Migration Activity: A Functional and Transcriptomic Analysis
L. Kurmann, M. Okoniewski, R.K. Dubey
Cells 10, 2314 (2021).
→ doi: 10.3390/cells10092314

Campylobacter jejuni genotypes are associated with post-infection irritable bowel syndrome in humans
S. Peters, B. Pascoe, Z. Wu, S.C. Bayliss, X. Zeng, A. Edwinson, S. Veerabadhran-Gurunathan, S. Jawahir, J.K. Calland, E. Mourkas, R. Patel, T. Wiens, M. Decuir, D. Boxrud, K. Smith, C.T. Parker, G. Farrugia, Q. Zhang, S.K. Sheppard, M. Grover
Commun. Biol. 4, 1015 (2021).
→ doi: 10.1038/s42003-021-02554-8

Transcriptome-wide profiling discover: PM2.5 aggravates airway dysfunction through epithelial barrier damage regulated by Stanniocalcin 2 in an OVA-induced model
L. Zhang, X. He, Y. Xiong, Q. Ran, A. Xiong, J. Wang, D. Wu, B. Niu, G. Li
Ecotoxicol. Environ. Saf. 220, 112408 (2021).
→ doi: 10.1016/j.ecoenv.2021.112408

Comparative sensitivity of proliferative and differentiated intestinal epithelial cells to the food contaminant, deoxynivalenol
S. Luo, Ch. Terciolo, M. Neves, S. Puel, Cl. Naylies, Y. Lippi, Ph. Pinton, I.P. Oswald
Environ. Pollut. 277, 116818 (2021).
→ doi: 10.1016/j.envpol.2021.116818

Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5)
C. Goldeman, M. Andersen, A. Al-Robai, T. Buchholtz, N. Svane, B. Ozgür, B. Holst, E. Shusta, V. Hall, L. Saaby, P. Hyttel, B. Brodin
Eur. J. Pharm. Sci. 156, 105577 (2021).
→ doi: 10.1016/j.ejps.2020.105577

The effect of ultrasound cavitation on endothelial cells
M.S. Karthikesh, X. Yang
Exp. Biol. Med. 246, 758 (2021).
→ doi: 10.1177/1535370220982301

Towards the development of a human in vitro model of the blood–brain barrier for virus-associated acute encephalopathy: assessment of the time- and concentration-dependent effects of TNF-a on paracellular tightness
H. Maeda, K. Hashimoto, H. Go, K. Miyazaki, M. Sato, Y. Kawasaki, N. Momoi, M. Hosoya
Exp. Brain Res. 239, 451 (2021).
→ doi: 10.1007/s00221-020-05985-7

Brain endothelial LRP1 maintains blood–brain barrier integrity
S.E. Storck, M. Kurtyka, C.U. Pietrzik
Fluids Barriers CNS 18, 27 (2021).
→ doi: 10.1186/s12987-021-00260-5

Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice
A. Cibelli, S.V. Lopez-Quintero, S. McCutcheon, E. Scemes, D.C. Spray, R.F. Stout Jr., S.O. Suadicani, M.M. Thi, M. Urban-Maldonado
Front. Cell. Neurosci. 15, 647109 (2021).
→ doi: 10.3389/fncel.2021.647109

Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells
N. Schäfer, A. Rasras, D.M. Ormenisan, S. Amslinger, V. Enzmann, H. Jägle, D. Pauly
Front. Immunol. 12, 769242 (2021).
→ doi: 10.3389/fimmu.2021.769242

A PCB-Based 24-Ch. MEA-EIS Allowing Fast Measurement of TEER
M. Rajabzadeh, J. Ungethüm, A. Herkle, C. Schilpp, J. Becker, M. Fauler, O. Wittekindt, M. Frick, M. Ortmanns
IEEE Sens. J. 21, 13048 (2021).
→ doi: 10.1109/JSEN.2021.3067823

Mycotoxines majeures et émergentes dans les filières cidre et vin: observatoire, lutte biologique au champ et devenir au cours des procédés
M. Coarer, O. Puel, S. Lorber, H. Guichard, J. Lemaguet, N. Corroyer, A. Camponovo, S. Boiry, M. Sabaty, L. Maguet, D. Caboulet, D. Solanet
Innovations Agronomiques 82, 246 (2021).
→ doi: 10.15454/6z4f-7s10

Cerebral Pericytes and Endothelial Cells Communicate through Inflammasome-Dependent Signals
M. Kozma, Á. Mészáros, Á. Nyúl-Tóth, K. Molnár, L. Costea, Z. Hernádi, C. Fazakas, A.E. Farkas, I. Wilhelm, I.A. Krizbai
Int. J. Mol. Sci. 22, 6122 (2021).
→ doi: 10.3390/ijms22116122

Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?
E.S. Sandin, J. Folberth, H. Müller-Fielitz, C.U. Pietrzik, E. Herold, T.E. Willnow, P.T. Pfluger, R. Nogueiras, V. Prevot, T. Krey, M. Schwaninger
Int. J. Mol. Sci. 22, 4998 (2021).
→ doi: 10.3390/ijms22094998

Lecithin coating as universal stabilization and functionalization strategy for nanosized drug carriers to overcome the blood–brain barrier
A.Wünsch, D.Mulac, K.Langer
Int. J. Pharm. 593, 120146 (2021).
→ doi: 10.1016/j.ijpharm.2020.120146

Electrical impedance measurement system to assess in-situ experiments on epithelia under ELF magnetic fields exposure
G. Domínguez, E. Cardiel, J.L. Reyes, E. Sánchez, P.R. Hernández
J. Appl. Res. Technol. 19, 217 (2021).
→ doi: 10.22201/icat.24486736e.2021.19.3.1693

PM2.5 Aggravated OVA-Induced Epithelial Tight Junction Disruption Through Fas Associated via Death Domain-Dependent Apoptosis in Asthmatic Mice
X. He, L. Zhang, L. Hu, S. Liu, A. Xiong, J. Wang, Y. Xiong, G. Li
J. Asthma Allergy 14, 1411 (2021).
→ doi: 10.2147/JAA.S335590

AMP-activated protein kinase is a key regulator of acute neurovascular permeability
S. Dragoni, B. Caridi, E. Karatsai, T. Burgoyne, M.H. Sarker, P. Turowski
J. Cell Sci. 134, jcs253179 (2021).
→ doi: 10.1242/jcs.253179

Tight junctions in the blood–brain barrier promote edema formation and infarct size in stroke – Ambivalent effects of sealing proteins
L. Winkler, R. Blasig, O. Breitkreuz-Korff, Ph. Berndt, S. Dithmer, H.C. Helms, D. Puchkov, K. Devraj, M. Kaya, Z. Qin, S. Liebner, H. Wolburg, A.V. Andjelkovic, A. Rex, I.E. Blasig, R.F. Haseloff
J. Cereb. Blood Flow Metab. 41, 132 (2021).
→ doi: 10.1177/0271678X20904687

Meprin ß: A novel regulator of blood–brain barrier integrity
M. Gindorf, S.E. Storck, A. Ohler, F. Scharfenberg, Ch. Becker-Pauly, C.U. Pietrzik
J. Cereb. Blood Flow Metab. 41, 31 (2021).
→ doi: 10.1177/0271678X20905206

Macrophage-mediated vascular permeability via VLA4/VCAM1 pathway dictates ascites development in ovarian cancer
S. Zhang, B. Xie, L. Wang, H. Yang, H. Zhang, Y. Chen, F. Wang, Ch. Liu, H. He
J. Clin. Invest. 131, e140315 (2021).
→ doi: 10.1172/JCI140315

Mechanism of Nucleic Acid Sensing in Retinal Pigment Epithelium (RPE): RIG-I Mediates Type I Interferon Response in Human RPE
J. Schustak, M. Twarog, X. Wu, H.Y. Wu, Q. Huang, Y. Bao
J. Immunol. Res. 2021, 9975628 (2021).
→ doi: 10.1155/2021/9975628

Counter-directed leucine gradient promotes amino acid transfer across the human placenta
J. Zaugga, F. Ziegler, J.-M. Nuoffer, R. Moser-Hässig, C. Albrecht
J. Nutr. Biochem. 96, 108760 (2021).
→ doi: 10.1016/j.jnutbio.2021.108760

Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damage
S. Borchard, S. Raschke, K.M. Zak, C. Eberhagen, C. Einer, E. Weber, S.M. Müller, B. Michalke, J. Lichtmannegger, A. Wieser, T. Rieder, G.M. Popowicz, J. Adamski, M. Klingenspor, A.H. Coles, R. Viana, M.H. Vendelbo, T.D. Sandahl, T. Schwerdtle, T. Plitz, H. Zischka
Life Sci. Alliance 5, e202101164 (2021).
→ doi: 10.26508/lsa.202101164

Development of an In Vitro Airway Epithelial–Endothelial Cell Culture Model on a Flexible Porous Poly(Trimethylene Carbonate) Membrane Based on Calu-3 Airway Epithelial Cells and Lung Microvascular Endothelial Cells
T. Pasman, D. Baptista, S. van Riet, R.K. Truckenmüller, P.S. Hiemstra, R.J. Rottier, N.M. Hamelmann, J.M.J. Paulusse, D. Stamatialis, Á.A. Poot
Membranes 11, 197 (2021).
→ doi: 10.3390/membranes11030197

Capabilities of selenoneine to cross the in vitro blood–brain barrier model
E. Drobyshev, S. Raschke, R.A. Glabonjat, J. Bornhorst, F. Ebert, D. Kuehnelt, T. Schwerdtle
Metallomics 13, mfaa007 (2021).
→ doi: 10.1093/mtomcs/mfaa007

Transendothelial Electrical Resistance Measurement across the Blood–Brain Barrier: A Critical Review of Methods
J.P. Vigh, A. Kincses, B. Ozgür, F.R. Walter, A.R. Santa-Maria, S. Valkai, M. Vastag, W. Neuhaus, B.B. Brodin, A. Dér, M.A. Deli
Micromachines 12, 685 (2021).
→ doi: 10.3390/mi12060685

New BBB Model Reveals That IL-6 Blockade Suppressed the BBB Disorder, Preventing Onset of NMOSD
Y. Takeshita, S. Fujikawa, K. Serizawa, M. Fujisawa, K. Matsuo, J. Nemoto, F. Shimizu, Y. Sano, H. Tomizawa-Shinohara, S. Miyake, R.M. Ransohoff, T. Kanda
Neurol. Neuroimmunol. Neuroinflamm. 8, e1076 (2021).
→ doi: 10.1212/NXI.0000000000001076

TGF-ß1 increases permeability of ciliated airway epithelia via redistribution of claudin 3 from tight junction into cell nuclei
C. Schilpp, R. Lochbaum, P. Braubach, D. Jonigk, M. Frick, P. Dietl, O.H. Wittekindt
Pfluegers Arch. 473, 287 (2021).
→ doi: 10.1007/s00424-020-02501-2

SZR-104, a Novel Kynurenic Acid Analogue with High Permeability through the Blood–Brain Barrier
K. Molnár, B. Lorinczi, C. Fazakas, I. Szatmári, F. Fülöp, N. Kmetykó, R. Berkecz, I. Ilisz, I.A. Krizbai, I. Wilhelm,L. Vécsei
Pharmaceutics 13, 61 (2021).
→ doi: 10.3390/pharmaceutics13010061

Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2a—Ve-Cadherin Pathway
D. Rand, O. Ravid, D. Atrakchi, H. Israelov, Y. Bresler, Ch. Shemesh, L. Omesi, S. Liraz-Zaltsman, F. Gosselet, T.S. Maskrey, M. Schnaider Beeri, P. Wipf, I. Cooper
Pharmaceutics 13, 311 (2021).
→ doi: 10.3390/pharmaceutics13030311

Astrocyte-derived Wnt growth factors are required for endothelial blood-brain barrier maintenance
S. Guerit, E. Fidan, J. Macas, C.J. CCzupalla, R. Figueiredo, A. Vijikumar, B.H. Yalcin, S. Thom, P. Winter, H. Gerhardt, K. Devraj, S. Liebner
Prog. Neurobiol. 199, 101937 (2021).
→ doi: 10.1016/j.pneurobio.2020.101937

Role of the C5a-C5a receptor axis in the inflammatory responses of the lungs after experimental polytrauma and hemorrhagic shock
S. Chakraborty, V.E. Winkelmann, S. Braumüller, A. Palmer, A. Schultze, B. Klohs, A. Ignatius, A. Vater, M. Fauler, M. Frick, M. Huber-Lang
Sci. Rep. 11, 2158 (2021).
→ doi: 10.1038/s41598-020-79607-1

Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo
K. Ernst, A.-K. Mittler, V. Winkelmann, C. Kling, N. Eberhardt, A. Anastasia, M. Sonnabend, R. Lochbaum, J. Wirsching, M. Sakari, A.T. Pulliainen, C. Skerry, N.H. Carbonetti, M. Frick, H. Barth
Sci. Rep. 11, 5429 (2021).
→ doi: 10.1038/s41598-021-84817-2

Repeated exposure of Caco-2 versus Caco-2/HT29-MTX intestinal cell models to (nano)silver in vitro: Comparison of two commercially available colloidal silver products
K. Gillois, Ch. Stoffels, M. Leveque, I. Fourquaux, J. Blesson, V. Mils, S. Cambier, J. Vignard, H. Terrisse, G. Mirey, J.-N. Audinot, V. Theodorou, M.-H. Ropers, H. Robert, M. Mercier-Bonin
Sci. Total Environ. 754, 14232 (2021).
→ doi: 10.1016/j.scitotenv.2020.142324

Microfluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screening
Y. Kohl, M. Biehl, S. Spring, M. Hesler, V. Ogourtsov, M. Todorovic, J. Owen, E. Elje, K. Kopecka, O.H. Moriones, N.G. Bastús, P. Simon, T. Dubaj, E. Rundén-Pran, V. Puntes, N. William, H. von Briesen, S. Wagner, N. Kapur, E. Mariussen, A. Nelson, A. Gabelova, M. Dusinska, Th. Velten, Th. Knoll
Small 17, e2006012 (2021).
→ doi: 10.1002/smll.202006012

HDAC inhibitor, MS-275, increases vascular permeability by suppressing Robo4 expression in endothelial cells
T. Kashio, K. Shirakura, M. Kinoshita, M. Morita, R. Ishiba, K. Muraoka, T. Kanbara, M. Tanaka, R. Funatsu, N. Hino, S. Koyama, R. Suzuki, Y. Yoshioka, T. Aoshi, T. Doi, Y. Okada
Tissue Barriers 9, e1911195 (2021).
→ doi: 10.1080/21688370.2021.1911195

Efflux at the Blood-Brain Barrier Reduces the Cerebral Exposure to Ochratoxin A, Ochratoxin a, Citrinin and Dihydrocitrinone
M. Behrens, S. Hüwel, H.-J. Galla, H.-U. Humpf
Toxins 13, 327 (2021).
→ doi: 10.3390/toxins13050327

Human Astroviruses: A Tale of Two Strains
V. Hargest, A.E. Davis, S. Tan, V. Cortez, S. Schultz-Cherry
Viruses 13, 376 (2021).
→ doi: 10.3390/v13030376



HIF-1a is involved in blood–brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis
G. Devraj, S. Guérit, J. Seele, D. Spitzer, J. Macas, M.I. Khel, R. Heidemann, A.K. Braczynski, W. Ballhorn, S. Günther, O.O. Ogunshola, M. Mittelbronn, U. Ködel, C.M. Monoranu, K.H. Plate, S. Hammerschmidt, R. Nau, K. Devraj, V.A.J. Kempf
Acta Neuropathol. 140, 183 (2020).
→ doi: 10.1007/s00401-020-02174-2

Combinatorial expression of claudins in the proximal renal tubule and ist functional consequences
J.N. Curry, S. Tokuda, P. McAnulty, A.S.L. Yu
Am. J. Renal. Physiol. 318, F1138 (2020).
→ doi: 10.1152/ajprenal.00057.2019

Lactobacillus rhamnosus GG Genomic and Phenotypic Stability in an Industrial Production Process
M. Stage, A. Wichmann, M. Jørgensen, N.I. Vera-Jimenéz, M. Wielje, D.S. Nielsen, A. Sandelin, Y. Chen, A. Baker
Appl. Environ. Microbiol. 86, e02780-19 (2020).
→ doi: 10.1128/AEM.02780-19

Aronia berry inhibits disruption of Caco-2 intestinal barrier function
J.C. Valdez, J. Cho, B.W. Bolling
Arch. Biochem. Biophys. 688, 108409 (2020).
→ doi: 10.1016/j.abb.2020.108409

Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation
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Quantitative analysis and virulence phenotypes of atypical enteropathogenic Escherichia coli (EPEC) acquired from diarrheal stool samples from a Midwest US hospital
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Enteropathogenic Escherichia coli (EPEC) Recruitment of PAR Polarity Protein Atypical PKC? to Pedestals and Cell–Cell Contacts Precedes Disruption of Tight Junctions in Intestinal Epithelial Cells
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Tight junctions in the blood–brain barrier promote edema formation and infarct size in stroke – Ambivalent effects of sealing proteins
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Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo
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The High Permeability of Nanocarriers Crossing the Enterocyte Layer by Regulation of the Surface Zonal Pattern
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In Vitro Effects of Live and Heat-Inactivated Bifidobacterium animalis Subsp. Lactis, BB-12 and Lactobacillus rhamnosus GG on Caco-2 Cells
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Monophosphoryl Lipid a Attenuates Multiorgan Dysfunction During Post-Burn Pseudomonas Aeruginosa Pneumonia in Sheep
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Enhanced Bioavailability by Orally Administered Sirolimus Nanocrystals
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Effect of E Cigarette Emissions on Tracheal Cells Monitored at the Air–Liquid Interface Using an Organic Electrochemical Transistor
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Non-pooled Human Platelet Lysate: A Potential Serum Alternative for In Vitro Cell Culture
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In vitro and in vivo effects of a mycotoxin, deoxynivalenol, and a trace metal, cadmium, alone or in a mixture on the intestinal barrier
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The impact of gastrointestinal mucus on nanoparticle penetration – in vitro evaluation of mucus-penetrating nanoparticles for photodynamic therapy
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Revisiting an old antibiotic: bacitracin neutralizes binary bacterial toxins and protects cells from intoxication
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PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation
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Autophagy Protects the Blood-Brain Barrier Through Regulating the Dynamic of Claudin-5 in Short-Term Starvation
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Structure and biological activities of a hexosamine-rich cell wall polysaccharide isolated from the probiotic Lactobacillus farciminis
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IL-13 Impairs Tight Junctions in Airway Epithelia
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Temporal Effects of Quercetin on Tight Junction Barrier Properties and Claudin Expression and Localization in MDCK II Cells
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The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers
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Controversial roles for dexamethasone in glioblastoma – Opportunities for novel vascular targeting therapies
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Short communication: Processed bovine colostrum milk protein concentrate increases epithelial barrier integrity of Caco-2 cell layers
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Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases
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Fucosyltransferase 4 and 7 mediates adhesion of non-small cell lung cancer cells to brain-derived endothelial cells and results in modification of the blood–brain-barrier: in vitro investigation of CD15 and CD15s in lung-to-brain metastasis
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Improved Drug Delivery to Brain Metastases by Peptide-Mediated Permeabilization of the Blood–Brain Barrier
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LRP1 Has a Predominant Role in Production over Clearance of Aß in a Mouse Model of Alzheimer’s Disease
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Side-directed Transfer and Presystemic Metabolism of Selenoneine in a Human Intestinal Barrier Model
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Polyphenol Extracts from Three Colombian Passifloras (Passion Fruits) Prevent Inflammation-Induced Barrier Dysfunction of Caco-2 Cells
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Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology
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Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide
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Targeting claudin-4 enhances CDDP-chemosensitivity in gastric cancer
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Corticosteroid signaling at the brain-immune interface impedes coping with severe psychological stress
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Claudin-3-deficient C57BL/6J mice display intact brain barriers
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Unraveling In Vivo Brain Transport of Protein-Coated Fluorescent Nanodiamonds
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The Antibiotic Bacitracin Protects Human Intestinal Epithelial Cells and Stem Cell-Derived Intestinal Organoids from Clostridium difficile Toxin TcdB
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Multi-endpoint toxicological assessment of polystyrene nano- and microparticles in different biological models in vitro
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Modelling Macular Edema: The Effect of IL-6 and IL-6R Blockade on Human Blood–Retinal Barrier Integrity In Vitro
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Brain Delivery of Multifunctional Dendrimer Protein Bioconjugates
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The GTPase ARFRP1 affects lipid droplet protein composition and triglyceride release from intracellular storage of intestinal Caco-2 cells
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Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function
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Reversible opening of the blood-brain barrier by claudin-5-binding variants of Clostridium perfringens enterotoxin's claudin-binding domain
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The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM
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HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model
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Mucus-penetrating nanoparticles: Promising drug delivery systems for the photodynamic therapy of intestinal cancer
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Real-time acquisition of transendothelial electrical resistance in an all-human, in vitro, 3-dimensional, blood–brain barrier model exemplifies tight-junction integrity
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Zika virus crosses an in vitro human blood brain barrier model
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Rho-Kinase Inhibition Ameliorates Dasatinib-Induced Endothelial Dysfunction and Pulmonary Hypertension
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Giardipain-1, a protease secreted by Giardia duodenalis trophozoites, causes junctional, barrier and apoptotic damage in epithelial cell monolayers
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Nonionic surfactants increase digoxin absorption in Caco-2 and MDCKII MDR1 cells: Impact on P-glycoprotein inhibition, barrier function, and repeated cellular exposure
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VLA-4 mediated adhesion of melanoma cells on the blood–brain barrier is the critical cue for melanoma cell intercalation and barrier disruption
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Monocultures of primary porcine brain capillary endothelial cells: Still a functional in vitro model for the blood-brain-barrier
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Alteration of sphingolipid metabolism as a putative mechanism underlying LPS-induced BBB disruption
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Arsenic-containing hydrocarbons disrupt a model in vitro blood-cerebrospinal fluid barrier
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N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration
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Targeting Voltage-Dependent Calcium Channels with Pregabalin Exerts a Direct Neuroprotective Effect in an Animal Model of Multiple Sclerosis
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A novel occludin-targeting monoclonal antibody prevents hepatitis C virus infection in vitro
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Telmisartan prevents diet-induced obesity and preserves leptin transport across the blood-brain barrier in high-fat diet-fed mice
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Bovine dairy complex lipids improve in vitro measures of small intestinal epithelial barrier integrity
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Rhombic organization of microvilli domains found in a cell model of the human intestine
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Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells
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A novel human induced pluripotent stem cell blood-brain barrier model: Applicability to study antibody-triggered receptor-mediated transcytosis
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Functionalization of gold-nanoparticles by the Clostridium perfringens enterotoxin C-terminus for tumor cell ablation using the gold nanoparticle-mediated laser perforation technique
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Optimized procedures for generating an enhanced, near physiological 2D culture system from porcine intestinal organoids
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Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy
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The organophosphate pesticide methamidophos opens the blood-testis barrier and covalently binds to ZO-2 in mice
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Towards quantification of toxicity of lithium ion battery electrolytes - development and validation of a liquid-liquid extraction GC-MS method for the determination of organic carbonates in cell culture materials
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Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function
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Chemokine CCL17 is expressed by dendritic cells in the CNS during experimental autoimmune encephalomyelitis and promotes pathogenesis of disease
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Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D
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Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration
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The ESRP1-GPR137 axis contributes to intestinal pathogenesis
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Loss of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice
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Andrographolide-loaded nanoparticles for brain delivery: Formulation, characterisation and in vitro permeability using hCMEC/D3 cell line
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Ouabain promotes partial epithelial to mesenchymal transition (EMT) changes in human autosomal dominant polycystic kidney disease (ADPKD) cells
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Regulated efflux of photoreceptor outer segment-derived cholesterol by human RPE cells
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Gb3-binding lectins as potential carriers for transcellular drug delivery
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Primary porcine brain endothelial cells as in vitro model to study effects of ultrasound on blood-brain barrier function
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Influence of the Fruit Juice Carriers on the Ability of Lactobacillus plantarum DSM20205 to Improve in Vitro Intestinal Barrier Integrity and Its Probiotic Properties
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Catalytically enhanced organic transistors for in vitro toxicology monitoring through hydrogel entrapment of enzymes
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Exfoliated graphene nanosheets: pH-sensitive drug carrier and anti-cancer activity
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Early-lactation, but not mid-lactation, bovine lactoferrin preparation increases epithelial barrier integrity of Caco-2 cell layers
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Real-time monitoring of trans-epithelial electrical resistance in cultured intestinal epithelial cells: the barrier protection of water-soluble dietary fiber
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Epithelial Barriers in Murine Skin during Herpes Simplex Virus 1 Infection: The Role of Tight Junction Formation
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Effect of Hops Derived Prenylated Phenols on TNF-a Induced Barrier Dysfunction in Intestinal Epithelial Cells
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Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis
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Assessment of Ocriplasmin Effects on the Vitreoretinal Compartment in Porcine and Human Model Systems
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Saccharomyces boulardii CNCM I-745 Restores intestinal Barrier Integrity by Regulation of E-cadherin Recycling
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Insights from mathematical modelling for T cell migration into the central nervous system
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The effects of gold nanoparticles functionalized with ß-amyloid specific peptides on an in vitro model of blood–brain barrier
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E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning
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Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy
J. Hu, S. Dziumbla, J. Lin, S.-I. Bibli, S. Zukunft, J. de Mos, K. Awwad, T. Frömel, A. Jungmann, K. Devraj, Z. Cheng, L. Wang, S. Fauser, Ch.G. Eberhart, A. Sodhi, B.D. Hammock, S. Liebner, O.J. Müller, C. Glaubitz, H.-P. Hammes, R. Popp, I. Fleming
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Live Faecalibacterium prausnitzii Does Not Enhance Epithelial Barrier Integrity in an Apical Anaerobic Co-Culture Model of the Large Intestine
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Establishment of a method for evaluating endothelial cell injury by tnF-a in vitro for clarifying the pathophysiology of virus-associated acute encephalopathy
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Development of Blood-Brain Barrier Permeable Nanoparticles as Potential Carriers for Salvianolic Acid B to CNS
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Cross-over endocytosis of claudins is mediated by interactions via their extracellular loops
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Opposing effects of in vitro differentiated macrophages sub-type on epithelial wound healing
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Dual role of ALCAM in neuroinflammation and blood–brain barrier homeostasis
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Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells
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Angiopoietin-2-induced blood–brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling
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Perilla Frutescens targets intestinal permeability In vitro study on TNF- a stress-induced barrier dysfunction in intestinal epithelial cells
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Plasmalemma Vesicle–Associated Protein Has a Key Role in Blood-Retinal Barrier Loss
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Differences in the molecular structure of the blood-brain barrier in the cerebral cortex and white matter: an in silico, in vitro and ex vivo study
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Validation of an immortalized human (hBMEC) in vitro blood-brain barrier model
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Early Detection of Nephrotoxicity In Vitro Using a Transparent Conducting Polymer Device
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ZOT-derived peptide and chitosan functionalized nanocarrier for oral delivery of protein drug
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Effects on and transfer across the blood-brain barrier in vitro — Comparison of organic and inorganic mercury species
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Secretion of Alpha-Hemolysin by Escherichia coli Disrupts Tight Junctions in Ulcerative Colitis Patients
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Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases
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EMBO Mol. Med. 8, 1265 (2016).

In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs
D.E. Eigenmann, C. Dürig, E.A. Jähne, M. Smieško, M. Culot, F. Gosselet, R. Cecchelli, H.Ch.C. Helms, B. Brodin, L. Wimmer, M.D. Mihovilovic, M. Hamburger, M. Oufir
Eur. J. Pharm. Biopharm. 103, 118 (2016).

Targeting of the kynurenic acid across the blood–brain barrier by core-shell nanoparticles
N. Varga, E. Csapó, Z. Majláth, I. Ilisz, I.A. Krizbai, I. Wilhelm, L. Knapp, J. Toldi, L. Vécsei, I. Dékány
Eur. J. Pharm. Sci. 86, 67 (2016).

Transient receptor potential A1 channels regulate epithelial cell barriers formed by MDCK cells
S. Dembla, N. Hasan, A. Becker, A. Beck, S.E. Philipp
FEBS Lett. 590, 1509 (2016).

Modeling immune functions of the mouse blood–cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier
I. Lazarevic, B. Engelhardt
Fluids Barriers CNS 13, 2 (2016).

MicroRNA-320a Strengthens Intestinal Barrier Function and Follows the Course of Experimental Colitis
F. Cordes, M. Brückner, P. Lenz, K. Veltman, R. Glauben, B. Siegmund, K. Hengst, M.A. Schmidt, Ch. Cichon, D. Bettenworth
Inflammatory Bowel Dis. 22, 2341 (2016).

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction
P.G. Sreekumar, K. Ishikawa, C.S., H.H. Mehta, J. Wan, K. Yen, P. Cohen, R. Kannan, D.R. Hinton
Invest. Ophthalmol. Visual Sci. 57, 1238 (2016).
→ doi: 10.1167/iovs.15-17053

Nucleoside diphosphate kinase B regulates angiogenic responses in the endothelium via caveolae formation and c-Src-mediated caveolin-1 phosphorylation
S. Gross, K. Devraj, Y. Feng, J. Macas, S. Liebner, T. Wieland
J. Cereb. Blood Flow Metab. 37, 2471 (2016).

Endothelial LRP1 transports amyloid-ß1-42 across the blood-brain barrier
S.E. Storck, S. Meister, J. Nahrath, J.N. Meißner, N. Schubert, A. Di Spiezio, S. Baches, R.E. Vandenbroucke, Y. Bouter, I. Prikulis, C. Korth, S. Weggen, A. Heimann, M. Schwaninger, T.A. Bayer, C.U. Pietrzik
J. Clin. Invest. 126, 123 (2016).

Flurbiprofen-loaded Nanoparticles Can Cross a Primary Porcine In vitro Blood-brain Barrier Model to Reduce Amyloid-ß42 Burden
J. Stab, I. Zlatev, B. Raudszus, S. Meister, C.U. Pietrzik, K. Langer, H. von Briesen, S. Wagner
J. Nanomed. Biother. Discovery 6, 1000140 (2016).

ß-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function
N. Ziegler, K. Awwad, B. Fisslthaler, M. Reis, K. Devraj, M. Corada, S.P. Minardi, E. Dejana, K.H. Plate, I. Fleming, S. Liebner
J. Neurosci. 36, 8921 (2016).

Validation of UHPLC–MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies
F. Moradi-Afrapoli, M. Oufir, F.R. Walter, M.A. Deli, M. Smiesko, V. Zabela, V. Butterweck, M. Hamburger
J. Pharm. Biomed. Anal. 128, 264 (2016).

The Effect of Capsaicin Derivatives on Tight-Junction Integrity and Permeability of Madin-Darby Canine Kidney Cells
M. Kaiser, S.Chalapala, C. Gorzelanny, R.S. Perali, F.M. Goycoolea
J. Pharm. Sci. 105, 630 (2016).

Toxicological characterisation of a thio-arsenosugar-glycerol in human cells
F. Ebert, S. Meyer, L. Leffers, G. Raber, K.A. Francesconi, T. Schwerdtle
J. Trace Elem. Med. Biol. 38, 150 (2016).

An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction
I. Kuzmanov, A.M. Herrmann, H.-J. Galla, S.G. Meuth, H. Wiendl, L. Klotz
J. Vis. Exp. 118, e54592 (2016).

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells
K. Göbel, S. Pankratz, Ch.-M. Asaridou, A.M. Herrmann, S. Bittner, M. Merker, T. Ruck, S. Glumm, F. Langhauser, P. Kraft, T.F. Krug, J. Breuer, M. Herold, C.C. Gross, D. Beckmann, A. Korb-Pap, M.K. Schuhmann, S. Kuerten, I. Mitroulis, C. Ruppert, M.W. Nolte, C. Panousis, L. Klotz, B. Kehrel, T. Korn, H.F. Langer, T. Pap, B. Nieswandt, H. Wiendl, T. Chavakis, Ch. Kleinschnitz, S.G. Meuth
Nat. Commun. 7, 11626 (2016).

Influence of Bovine Whey Protein Concentrate and Hydrolysate Preparation Methods on Motility in the Isolated Rat Distal Colon
J.E. Dalziel, R.C. Anderson, S.A. Bassett, C.M. Lloyd-West, N.W. Haggarty, N.C. Roy
Nutrients 8, 809 (2016).

Pharmacokinetics and In Vitro Blood-Brain Barrier Screening of the Plant-Derived Alkaloid Tryptanthrin
E.A. Jähne, D.E. Eigenmann, Ch. Sampath, V. Butterweck, M. Culot, R. Cecchelli, F. Gosselet, F.R. Walter, M.A. Deli, M. Smieško, M. Hamburger, M. Oufir
Planta Med. 82, 1021 (2016).

B7-H1 shapes T-cell–mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity
L. Klotz, I. Kuzmanov, S. Hucke, C.C. Gross, V. Posevitz, A. Dreykluft, A. Schulte-Mecklenbeck, C. Janoschka, M. Lindner, M. Herold, N. Schwab, I. Ludwig-Portugall, Ch. Kurts, S.G. Meuth, T. Kuhlmann, H. Wiendl
PNAS 113, E6182 (2016).

Thermo-responsive cell culture carriers based on poly(vinyl methyl ether)—the effect of biomolecular ligands to balance cell adhesion and stimulated detachment
J. Teichmann, M. Nitschke, D. Pette, M. Valtink, S. Gramm, F.V. Härtel, T. Noll, R.H.W. Funk, K. Engelmann, C. Werner
Sci. Technol. Adv. Mater. 16, 45003 (2016).

Human Alpha-Defensin HNP1 Increases HIV Traversal of the Epithelial Barrier: A Potential Role in STI-Mediated Enhancement of HIV Transmission
K. Valere, A. Rapista, E. Eugenin, W. Lu, T.L. Chang
Viral Immunol. 28, 609 (2016).



Transport of treosulfan and temozolomide across an in-vitro blood-brain barrier model
U. Linz, M. Hupert, B. Santiago-Schübel, S. Wien, J. Stab, S. Wagner
Anticancer Drugs 26, 728 (2015).

Organic electrochemical transistors for cell-based impedance sensing
J. Rivnay, M. Ramuz, P. Leleux, A. Hama, M. Huerta, R.M. Owens
Appl. Phys. Lett. 106, 43301 (2015).

Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers
C. Staat, C. Coisne, S. Dabrowski, S.M. Stamatovic, A.V. Andjelkovic, H. Wolburg, B. Engelhardt, I.E. Blasig
Biomaterials 54, 9 (2015).

Live Faecalibacterium prausnitzii in an apical anaerobic model of the intestinal epithelial barrier
D. Ulluwishewa, R.C. Anderson, W. Young, W.C. McNabb, P. van Baarlen, P.J. Moughan, J.M. Wells, N.C. Roy
Cell Microbiol. 17, 226 (2015).

Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier
M. Abadier, J. Haghayegh Jahromi, L. Cardoso Alves, R. Boscacci, D. Vestweber, S. Barnum, U. Deutsch, B. Engelhardt, R. Lyck
Eur. J. Immunol. 45, 1043 (2015).

Expression of the ALS-causing variant hSOD1G93A leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood–spinal cord barrier model
S. Meister, S. Storck, E. Hameister, C. Behl, S. Weggen, A. Clement, C. Pietrzik
J. Cereb. Blood Flow Metab. 35, 1112 (2015).

Nanotoxicity of poly(n-butylcyano-acrylate) nanoparticles at the blood–brain barrier, in human whole blood and in vivo
M. Kolter , M. Ott, C. Hauer, I. Reimold, G. Fricker
J. Control Release 197, 165 (2015).

Irsogladine Maleate Regulates Gap Junctional Intercellular Communication-Dependent Epithelial Barrier in Human Nasal Epithelial Cells
R. Miyata, K. Nomura, T. Kakuki, K. Takano, T. Kohno, T. Konno, N. Sawada, T. Himi, T. Kojima
J. Membr. Biol. 248, 327 (2015).

In Vitro Blood–Brain Barrier Models—An Overview of Established Models and New Microfluidic Approaches
A. Wolff, M. Antfolk, B. Brodin, M. Tenje
J. Pharm. Sci. 104, 2727 (2015).

Non-Saccharomyces yeasts protect against epithelial cell barrier disruption induced by Salmonella enterica subsp. enterica serovar Typhimurium
I.M. Smith, A. Baker, N. Arneborg, L. Jespersen
Lett. Appl. Microbiol. 61, 491 (2015).

The blood–cerebrospinal fluid barrier – first evidence for an active transport of organic mercury compounds out of the brain
H. Lohren, J. Bornhorst, H.J. Galla, T. Schwerdtle
Metallomics 7, 1420 (2015).

Arsenic-containing hydrocarbons and arsenic-containing fatty acids: Transfer across and presystemic metabolism in the Caco-2 intestinal barrier model
S. Meyer, G. Raber, F. Ebert, M.S. Taleshi, K.A. Francesconi, T. Schwerdtle
Mol. Nutr. Food Res. 59, 2044 (2015).

Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier
A. Bernd, M. Ott, H. Ishikawa, H. Schroten, C. Schwerk, G. Fricker
Pharm. Res. 32, 2973 (2015).

Claudin-4 binder C-CPE 194 enhances effects of anticanceragents on pancreatic cancer cell lines via a MAPK pathway
K. Tsuyoshi, K. Masuo, K. Daisuke, I. Tatsuya, K. Yasutoshi, I. Masafumi, K. Takayuki, K. Takumi, F. Tomohisa, S. Norimasa, H. Koichi, K. Takashi
Pharmacol. Res. Perspect. 3, e00196 (2015).

Intestinal formation of trans-crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier
M. Lautenschläger, J. Sendker, S. Hüwel, H.J. Galla, S. Brandt, M. Düfer, K. Riehemann, A. Hensel
Phytomed. 22, 36 (2015).

ANKS1B Interacts with the Cerebral Cavernous Malformation Protein-1 and Controls Endothelial Permeability but Not Sprouting Angiogenesis
S.E. Herberich, R. Klose, I. Moll, W.-J. Yang, J. Wüstehube-Lausch, A. Fischer
PLoS One 10, e0145304 (2015).

Blood-Brain Barrier Effects of the Fusarium Mycotoxins Deoxynivalenol, 3 Acetyldeoxynivalenol, and Moniliformin and Their Transfer to the Brain
M. Behrens, S. Hüwel, H.-J. Galla, H.-U. Humpf
PLoS One 10, e0143640 (2015).

Dynamic Regulation of a Cell Adhesion Protein Complex Including CADM1 by Combinatorial Analysis of FRAP with Exponential Curve-Fitting
M. Sakurai-Yageta, T. Maruyama, T. Suzuki, K. Ichikawa, Y. Murakami
PLoS One 10, e0116637 (2015).

Endothelial-Mesenchymal Transition of Brain Endothelial Cells: Possible Role during Metastatic Extravasation
I.A. Krizbai, Á. Gasparics, P. Nagyoszi, C. Fazakas, J. Molnár, I. Wilhelm, R. Bencs, L. Rosivall, A. Sebe
PLoS One 10, e0123845 (2015).

Chitosan encapsulation modulates the effect of capsaicin on the tight junctions of MDCK cells
M. Kaiser, S. Pereira, L. Pohl, S. Ketelhut, B. Kemper, C. Gorzelanny, H.J. Galla, B. M. Moerschbacher, F.M. Goycoolea
Sci. Rep. 5, 10048 (2015).

Using white noise to gate organic transistors for dynamic monitoring of cultured cell layers
J. Rivnay, P. Leleux, A. Hama, M. Ramuz, M. Huerta, G.G. Malliaras, R.M. Owens
Sci. Rep. 5, 11613 (2015).

Thermo-responsive cell culture carriers based on poly(vinyl methyl ether)—the effect of biomolecular ligands to balance cell adhesion and stimulated detachment
J. Teichmann, M. Nitschke, D. Pette, M. Valtink, S. Gramm, F.V. Härtel, T. Noll, R.H.W. Funk, K. Engelmann, C. Werner
Sci. Technol. Adv. Mater. 16, 45003 (2015).

Human Alpha-Defensin HNP1 Increases HIV Traversal of the Epithelial Barrier: A Potential Role in STI-Mediated Enhancement of HIV Transmission
K. Valere, A. Rapista, E. Eugenin, W. Lu, T.L. Chang
Viral Immunol. 28, 609 (2015).



Dynamic Monitoring of Salmonella typhimurium Infection of Polarized Epithelia Using Organic Transistors
S.A. Tria, M. Ramuz, M. Huerta, P. Leleux, J. Rivnay, L.H. Jimison, A. Hama, G.G. Mall
Adv. Healthcare Mater. 3, 1053 (2014).

Highly Conserved Cysteines Are Involved in the Oligomerization of Occludin-Redox Dependency of the Second Extracellular Loop
Ch. Bellmann, S. Schreivogel, R. Günther, S. Dabrowski, M. Schümann, H. Wolburg, I.E. Blasig
Antioxid. Redox Signaling 20, 855 (2014).

Dietary Xylo-oligosaccharide stimulates intestinal bifidobacteria and lactobacilli but has limited effect on intestinal integrity in rats
E.G. Christensen, T.R. Licht, T.D. Leser, M.I. Bahl
BMC Res. Notes 7, 660 (2014).

The antimicrobial protein S100A7/psoriasin enhances theexpression of keratinocyte differentiation markers andstrengthens the skin’s tight junction barrier
F. Hattori, C. Kiatsurayanon, K. Okumura, H. Ogawa, S. Ikeda, K. Okamoto, F. Niyonsaba
Br. J. Dermatol. 171, 742 (2014).

In Vitro Models of the Blood–Brain Barrier
C.J. Czupalla, S. Liebner, K. Devraj
Cerebral Angiogenesis Method Molec. Biol. 1135, 415 (2014).
→ doi: 10.1007/978-1-4939-0320-7_34

Differential apicobasal VEGF signaling at vascular blood-neural barriers
N. Hudson, M.B. Powner, M.H. Sarker, T. Burgoyne, M. Campbell, Z.K. Ockrim, R. Martinelli, C.E. Futter, M.B. Grant, P.A. Fraser, D.T. Shima, J. Greenwood, P. Turowski
Dev. Cell. 30, 541 (2014).

Freeze-drying of HI-6-loaded recombinant human serum albumin nanoparticles for improved storage stability
M. Dadparvar, S. Wagner, S. Wien, F. Worek, H. von Briesen, J. Kreuter
Euro. J. Pharm. Biopharm. 88, 510 (2014).

The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers
M.K. Nøhra, S.H. Hansena, B. Brodin, R. Holm, C.U. Nielsen
Euro. J. Pharm. Sci. 51, 1 (2014).

Increased Efflux of Amyloid-ß Peptides through the Blood-Brain Barrier by Muscarinic Acetylcholine Receptor Inhibition Reduces Pathological Phenotypes in Mouse Models of Brain Amyloidosis
P. Paganetti, K. Antoniello, K. Devraj, N. Toni, D. Kieran, R. Madani, M. Pihlgren, O. Adolfsson, W. Froestl, A. Schrattenholz, S. Liebner, D. Havas, M. Windisch, J.R. Cirrito, A. Pfeifer, A. Muhs
J. Alzheimer's Disease 38, 767 (2014).

Comprehensive Cysteine-Scanning Mutagenesis Reveals Claudin-2 Pore-Lining Residues with Different Intrapore Locations
J. Li, M. Zhuo, L. Pei, M. Rajagopa, A.S.L. Yu
J. Biol. Chem. 289, 6475 (2014).

Lipocalin-2 deficiency attenuates neuroinflammation and brain injury after transient middle cerebral artery occlusion in mice
M. Jin, J.-H. Kim, E. Jang, Y.M. Lee, H.S. Han, D.K. Woo, D.H. Park, H. Kook, K. Suk
J. Cereb. Blood Flow Metab. 34, 1306 (2014).

The Human Cathelicidin LL-37 Host Defense Peptide Upregulates Tight Junction-Related Proteins and Increases Human Epidermal Keratinocyte Barrier Function
T. Akiyama, F. Niyonsaba, Ch. Kiatsurayanon, T.T. Nguyen, H. Ushio, T. Fujimura, T. Ueno, K. Okumura, H. Ogawa, S. Ikeda
J. Innate Immun. 6, 739 (2014).

The M1 Protein of Streptococcus pyogenes Triggers an Innate Uptake Mechanism into Polarized Human Endothelial Cells
A. Ochel, M. Rohde, G.S. Chhatwal, S.R. Talay
J. Innate Immun. 6, 585 (2014).

Host Defense (Antimicrobial) Peptide, Human ß-Defensin-3, Improves the Function of the Epithelial Tight-Junction Barrier in Human Keratinocytes
C. Kiatsurayanon, F. Niyonsaba, R. Smithrithee, T. Akiyama, H. Ushio, M. Hara, K. Okumura, S. Ikeda, H. Ogawa
J. Invest. Dermatol. 134, 2163 (2014).

Synthesis and Pharmacological Evaluation of 5-Pyrrolidinylquinoxalines as a Novel Class of Peripherally Restricted ?-Opioid Receptor Agonists
C. Bourgeois, E. Werfel, F. Galla, K. Lehmkuhl, H. Torres-Gómez, D. Schepmann, B. Kögel, T. Christoph, W. Straßburger, W. Englberger, M. Soeberdt, S. Hüwel, H.-J. Galla, B. Wünsch
J. Med. Chem. 57, 6845 (2014).

PACAP Enhances Barrier Properties of Cerebral Microvessels
I. Wilhelm, C. Fazakas, A. Tamás, G. Tóth, D. Regl, I.A. Krizbai
J. Mol. Neurosci. 54, 469 (2014).
→ doi: 10.1007/s12031-014-0260-4

The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro
S. Cramer, S. Tacke, J. Bornhorst, J. Klingauf, T. Schwerdtle, H.-J. Galla
J. Nanomed. Nanotechnol. 5, 225 (2014).

Evaluation of Lignans from Heliopsis helianthoides var. scabra for Their Potential Antimetastatic Effects in the Brain
Z. Hajdu, J. Haskó, I.A. Krizbai, I. Wilhelm, N. Jedlinszki, C. Fazakas, J. Molnár, P. Forgo, J. Hohmann, D. Csupor
J. Nat. Prod. 77, 2641 (2014).

Development and validation of a LC–MS/MS method for assessment of an anti-inflammatory indolinone derivative by in vitro blood–brain barrier models
E.A. Jähne, D.E. Eigenmann, M. Culot, R. Cecchelli, F.R. Walter, M.A. Deli, R. Tremmel, G. Fricker, M. Smiesko, M. Hamburger, M. Oufir
J. Pharm. Biomed. Anal. 98, 235 (2014).
→ doi: 10.1016/j.jpba.2014.05.026

What Is the Mechanism Behind Increased Permeation Rate of a Poorly Soluble Drug from Aqueous Dispersions of an Amorphous Solid Dispersion?
K.J. Frank, U. Westedt, K.M. Rosenblatt, P. Hölig, J. Rosenberg, M. Mägerlein, G. Fricker, M. Brandl
J. Pharm. Sci. 103, 1779 (2014).

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
S.A. Tria, M. Ramuz, L.H. Jimison, A. Hama, R.M. Owens
J. Visualized Exp. 84, e51102 (2014).

Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice
S.W. Park, J.H. Kim, I. Mook-Jung, K.-W. Kim, W.J. Park, K.H. Park, J.H. Kim
Neurobiol. Aging 35, 2013 (2014).

Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation
K. Ridder, S. Keller, M. Dams, A.-K. Rupp, J. Schlaudraff, D. Del Turco, J. Starmann, J. Macas, D. Karpova, K. Devraj, C. Depboylu, B. Landfried, B. Arnold, K.H. Plate, G. Höglinger, H. Sültmann, P. Altevogt, S. Momma
PLoS Biol. 12, e1001874 (2014).

Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells.
K. Nomura, K. Obata, T. Keira, R. Miyata, S. Hirakawa, K. Takano, T. Kohno, N. Sawada, T. Himi, T. Kojima
Respir. Res. 15, 21 (2014).



Nanoparticulate flurbiprofen reduces amyloid-ß42 generation in an in vitro blood–brain barrier model
S. Meister, I. Zlatev, J. Stab, D. Docter, S. Baches, R.H. Stauber, M. Deutsch, R. Schmidt, S. Ropele, M. Windisch, K. Langer, S. Wagner, H. von Briesen, S. Weggen, C.U. Pietrzik
Alzheimer's Res. Ther. 5, 51 (2013).

Validation of the organic electrochemical transistor for in vitro toxicology
S. Tria, L.H. Jimison, A. Hama, M. Bongo, R.M. Owens
Biochim. Biophys. Acta 1830, 4381 (2013).

Sensing of EGTA Mediated Barrier Tissue Disruption with an Organic Transistor
S. Tria, L.H. Jimison, A. Hama, M. Bongo, R.M. Owens
Biosen. 3, 44 (2013).

Vectorial secretion of interleukin-8 mediates autocrine signalling in intestinal epithelial cells via apically located CXCR1
O. Rossi , J. Karczewski, E.H. Stolte, R.J.M. Brummer, M.A. van Nieuwenhoven, M. Meijerink, J.R.J. van Neerven, S.C.D. van Ijzendoorn, P. van Baarlen, J.M. Wells
BMC Res. Notes 6, 431 (2013).

Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro
C.U. Nielsen, S. Frølund, S. Abdulhadi, H. Sari, L. Langthaler, M.K. Nøhr, M.A. Kall, B. Brodin, R. Holm
Br. J. Pharmacol. 170, 1041 (2013).

Constitutive androstane receptor upregulates Abcb1 and Abcg2 at the blood–brain barrier after CITCO activation
J. Lemmen, I.E.P. Tozakidis, P. Bele, H.J. Galla
Brain Res. 1501, 68 (2013).

Pregnane X receptor upregulates ABC-transporter Abcg2 and Abcb1 at the blood-brain barrier
J. Lemmen, I.E.P. Tozakidis, H.J. Galla
Brain Res. 1491, 1 (2013).

Acetaminophen Changes Intestinal Epithelial Cell Membrane Properties, Subsequently Affecting Absorption Processes
C. Schäfer, K.R. Schröder, O. Höglinger, S. Tollabimazraehno, M.R. Lornejad-Schäfer
Cell Physiol. Biochem. 32, 431 (2013).

Regulation of tight junctions by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano
M. Someya, T. Kojima, M. Ogawa, T. Ninomiya, K. Nomura, A. Takasawa, M. Murata, S. Tanaka, T. Saito, N. Sawada
Cell Tissue Res. 354, 481 (2013).

Physicochemical characterization and in vitro permeation of an indirubin derivative
N. Heshmati, B. Wagner, X. Cheng, T. Scholz, M. Kansy, G. Eisenbrand, G. Fricker
Eur. J. Pharm. Sci. 50, 467 (2013).

Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood-brain barrier model for drug permeability studies
D.E. Eigenmann, G. Xue, K.S. Kim KS, A.V. Moses, M. Hamburger, M. Oufir
Fluids Barriers CNS 10, 33 (2013).
→ doi: 10.1186/2045-8118-10-33

Impedance-based cell monitoring: barrier properties and beyond
K. Benson, S. Cramer, H.J. Galla
Fluids Barriers CNS 10, 5 (2013).

Expression of Shiga toxin 2e glycosphingolipid receptors of primary porcine brain endothelial cells and toxin-mediated breakdown of the blood-brain barrier
I. Meisen, R. Rosenbrück, H.J. Galla, S. Hüwel, I.U. Kouzel, M. Mormann, H. Karch, J. Müthing
Glycobiol. 23, 745 (2013).

Transepithelial permeability studies of flavan-3-ol-C-glucosides and procyanidin dimers and trimers across the Caco-2 cell monolayer
S. Hemmersbach, S.S. Brauer, S. Hüwel, H.J. Galla, H.U. Humpf
J. Agric. Food Chem. 61, 7932 (2013).

The biocompatibility of a polyelectrolyte vitreous body substitute on a high resistance in vitro model of the blood-retinal barrier
F. Strotmann, I. Wolf, H.-J. Galla
J. Biomater. Appl. 28, 334 (2013).

The cytokine response of U937-derived macrophages infected through antibody dependent enhancent of dengue virus disrupts cell apical junctional complexes and increase vascular permeability
H. Puerta-Guardo, A. Raya-Sandino, L. González-Mariscal, V.H. Rosales, J. Ayala-Dávila, B. Chávez-Mungía, D. Martínez-Fong, F. Medina, J.E. Ludert, R. María del Angel
J. Virol. 87, 7486 (2013).

In vitro intestinal bioavailability of arsenosugar metabolites and presystemic metabolism of thio-dimethylarsinic acid in Caco-2 cells
L. Leffers, C.A. Wehe, S. Hüwel, M. Bartel, F. Ebert, M.S. Taleshi, H.-J. Galla, U. Karst, K.A. Francesconie, T. Schwerdtle
Metallomics 5, 1031 (2013).

In vitro toxicological characterization of two arsenosugars and their metabolites
L. Leffers, F. Ebert, M.S. Taleshi, K.A. Francesconi, T. Schwerdtle
Mol. Nutr. Food Res. 57, 1270 (2013).

Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS
S. Bittner, T. Ruck, M.K. Schuhmann, A.M. Herrmann, H. Moha ou Maati, N. Bobak, K. Göbel, F. Langhauser, D. Stegner, P. Ehling, M. Borsotto, H.-C. Pape, B. Nieswandt, C. Kleinschnitz, C. Heurteaux, H.-J. Galla, T. Budde, H. Wiendl, S.G. Meuth
Nat. Med. 19, 1161 (2013).

CD4+NKG2D+ T Cells Exhibit Enhanced Migratory and Encephalitogenic Properties in Neuroinflammation
T. Ruck, S. Bittner, C.C. Gross, J. Breuer, S. Albrecht, S. Korr, K. Göbel, S. Pankratz, C.M. Henschel, N. Schwab, O. Staszewski, M. Prinz, T. Kuhlmann, S.G. Meuth, H. Wiendl
PLoS ONE 8, e70225 (2013).

Curcumin Prevents Replication of Respiratory Syncytial Virus and the Epithelial Responses to It in Human Nasal Epithelial Cells
K. Obata, T. Kojima, T. Masaki, T. Okabayashi, S. Yokota, S. Hirakawa, K. Nomura, A. Takasawa, M. Murata, S. Tanaka, J. Fuchimoto, N. Fujii, H. Tsutsumi, T. Himi, N. Sawada
PLoS ONE 8, e70225 (2013).

Influence of T-2 and HT-2 Toxin on the Blood-Brain Barrier In Vitro: New Experimental Hints for Neurotoxic Effects.
M. Weidner, S. Hüwel, F. Ebert, T. Schwerdtle, H.J. Galla, H.U. Humpf
PLoS ONE 8, e60484 (2013).

Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier In Vitro
R. Paolinelli, M. Corada, L. Ferrarini, K. Devraj, C. Artus, C.J. Czupalla, N. Rudini, L. Maddaluno, E. Papa, B. Engelhardt, P.O. Couraud, S. Liebner, E. Dejana
PLoS One 8, e70233 (2013).



Receptor-Mediated Delivery of Magnetic Nanoparticles across the Blood–Brain Barrier
R. Qiao, Q. Jia, S. Hüwel, R. Xia, T. Liu, F. Gao, H.J. Galla, M. Gao
ACS Nano 6, 3304 (2012).

Differential Targeting of the E-Cadherin/ß-Catenin Complex by Gram-positive Probiotic Lactobacilli Improves Epithelial Barrier Function
S. Hummel, K. Veltman, C. Cichon, U. Sonnenborn, M.A. Schmidt
Appl. Environ. Microbiol. 78, 1140 (2012).

Inhibitory effect of phospholipids on P-glycoprotein: Cellular studies in Caco-2, MDCKII mdr1 and MDCKII wildtype cells and P-gp ATPase activity measurements
S. Simon, R. Schubert
Biochim. Biophys. Acta 1821, 1211 (2012).

Streptococcus pneumoniae induces exocytosis of Weibel-Palade bodies in pulmonary endothelial cells
M. Lüttge, M. Fulde, S.R. Talay, A. Nerlich, M. Rohde, K.T. Preissner, S. Hammerschmidt, M. Steinert, T.J. Mitchell, G.S. Chhatwal, S. Bergmann
Cell. Microbiol. 14, 210 (2012).

Impact of FaSSIF on the solubility and dissolution-/permeation rate of a poorly water-soluble compound
K. J. Frank, U. Westedt, K. M. Rosenblatt, P. Hölig, J. Rosenberg, M. Mägerlein, M. Brandl, G. Fricker
Euro. J. Pharm. Sci. 47, 16 (2012).

Identification of specific miRNAs targeting proteins of the apical junctional complex that simulate the probiotic effect of E. coli Nissle 1917 on T84 epithelial cells
K. Veltman, S. Hummel, C. Cichon, U. Sonnenborn, M.A. Schmidt
Int. J. Biochem. Cell Biol. 44, 341 (2012).

Amorphous solid dispersion enhances permeation of poorly soluble ABT-102: True supersaturation vs. apparent solubility enhancement
K.J. Frank, K.M. Rosenblatt, U. Westedt, P. Hölig, J. Rosenberg, M. Mägerlein, G. Fricker, M. Brandl
Int. J. Pharm. 437, 288 (2012).

Impact of manganese on and transfer across the blood-brain and blood-CSF barrier in vitro
J. Bornhorst, C.A. Wehe, S. Hüwel, U. Karst, H.J. Galla, T. Schwerdtle
J. Biol. Chem. 287, 17140 (2012).

Mechanism of Clostridium perfringens Enterotoxin Interaction with Claudin-3/-4 Protein Suggests Structural Modifications of the Toxin to Target Specific Claudins
A. Veshnyakova, J. Piontek, J. Protze, N. Waziri, I. Heise, G. Krause
J. Biol. Chem. 287, 1698 (2012).

aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation
S. Iden, S. Misselwitz, S.S.D. Peddibhotla, H. Tuncay, D. Rehder, V. Gerke, H. Robenek, A. Suzuki, K. Ebnet
J. Cell. Biol. 196, 623 (2012).

Preparation and properties of nanoscale containers for biomedical application in drug delivery: preliminary studies with kynurenic acid
V. Hornok, T. Bujdosó, J. Toldi, K. Nagy, I. Demeter, C. Fazakas, I. Krizbai, L. Vécsei, I. Dékány
J. Neural. Transm. 119, 115 (2012).

Cellular Interactions of a Water-Soluble Supramolecular Polymer Complex of Carbon Nanotubes with Human Epithelial Colorectal Adenocarcinoma Cells
Y. Lee, K. E. Geckeler
Macro. Biosci. 12, 1060 (2012).

Permeability of ergot alkaloids across the blood–brain barrier in vitro and influence on the barrier integrity
D. Mulac, S. Hüwel, H.J. Galla, H.U. Humpf
Mol. Nutr. Food Res. 56, 475 (2012).



In vitro models of the blood-brain barrier
I. Wilhelm, C. Fazakas, I. A. Krizbai
Acta Neurobiol. Exp. 71, 113 (2011).

Transport of Poly(n-butylcyano-acrylate) nanoparticles across the blood–brain barrier in vitro and their influence on barrier integrity
R. Rempe, S. Cramer, H.J. Galla
Biochem. Biophys. Res. Commun. 406, 64 (2011).

Neutrophils cross the BBB primarily on transcellular pathways: An in vitro study
M. von Wedel-Parlow, S. Schrot, J. Lemmen, L. Treeratanapiboon, J. Wegener, H.J. Galla
Brain Res. 1367, 62 (2011).

The impact of pericytes on the blood–brain barrier integrity depends critically on the pericyte differentiation stage
G. Thanabalasundaram, J. Schneidewind, C. Pieper, H.J. Galla
Int. J. Biochem. Cell Biol. 43, 1284 (2011).

Transport of Arylsulfatase A across the Blood-Brain Barrier in Vitro
F. Matthes, P. Wölte, A. Böckenhoff, S. Hüwel, M. Schulz, P. Hyden, J. Fogh, V. Gieselmann, H.J. Galla, U.Matzner
J. Biol. Chem. 286, 17487 (2011).

Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo
M. Schnoor, F.P.L. Lai, A. Zarbock, R. Kläver, C. Polaschegg, D. Schulte, H.A. Weich, J.M. Oelkers, K. Rottner, D. Vestweber
J. Exp. Med. 208, 1721 (2011).

Interactions of the prion peptide (PrP 106–126) with brain capillary endothelial cells: coordinated cell killing and remodeling of intercellular junctions
I. Cooper, K.C.-K. Malina, A. Cagnotto, G. Bazzoni, M. Salmona, V.I. Teichberg
J. Neurochem. 116, 467 (2011).

Effect of the non-ionic surfactant Poloxamer 188 on passive permeability of poorly soluble drugs across Caco-2 cell monolayers
S.M. Fischer, M. Brandl, G. Fricker
J. Pharm. Biopharm. 79, 416 (2011).

Transmigration of Melanoma Cells through the Blood-Brain Barrier: Role of Endothelial Tight Junctions and Melanoma-Released Serine Proteases
C. Fazakas, I. Wilhelm, P. Nagyöszi, A.E. Farkas, J. Hasko, J. Molnar, H. Bauer, H.C. Bauer, F. Ayaydin, N.T.K. Dung, L. Siklos, I.A. Krizbai
PLoS ONE 6, e20758 (2011).

HI 6 human serum albumin nanoparticles - Development and transport over an in vitro blood-brain barrier model
M. Dadparvara, S. Wagner, S. Wien, J. Kufleitner, F. Worek, H. von Briesen, J. Kreutera
Tox. Lett. 206, 60 (2011).



Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier
J. Karczewski, F.J. Troost, I. Konings, J. Dekker, M. Kleerebezem, R.-J.M. Brummer, J.M. Wells
Am. J. Physiol. Gastrointest. Liver Physiol. 298, G851 (2010).
→ doi: 10.1152/ajpgi.00327.2009

In vitro-Testverfahren zur Toxikologie von Nanomaterialien
A. Kroll, D. Hahn, J. Schnekenburger
BIOspectrum 16, 48 (2010).

Metalloproteinase mediated occludin cleavage in the cerebral microcapillary endothelium under pathological conditions
M. Lischper, S. Beuck, G. Thanabalasundaram, C. Pieper, H.J. Galla
Brain Res. 1326, 114 (2010).

Regulation of the blood-brain barrier integrity by pericytes via matrix metalloproteinases mediated activation of vascular endothelial growth factor in vitro
G. Thanabalasundaram, C. Pieper, M. Lischper, H.J. Galla
Brain Res. 1347, 1 (2010).
→ doi: 10.1016/j.brainres.2010.05.096

Characterization of immortalized choroid plexus epithelial cell lines for studies of transport processes across the blood-cerebrospinal fluid barrier
J. Kläs, H. Wolburg, T. Terasaki, G. Fricker, V. Reichel
Cerebrospinal Fluid Res. 7, 11 (2010).

In vitro evaluation of liposomes containing bio-enhancers for the oral delivery of macromolecules
J. Parmentier, F.J. Hartmann, G. Fricker
Euro. J. Pharm. Biopharm. 76, 394 (2010).

Epithelial Barrier Resistance is Increased by the Divalent Cation Zinc in Cultured MDCKII Epithelial Monolayers
G. Carr, J.A. Wright, N.L. Simmons
J. Membr. Biol. 237, 115 (2010).

Functionalized gold nanoparticles: a detailed in vivo multimodal microscopic brain distribution study
F. Sousa, S. Mandal,C. Garrovo, A. Astolfo, A. Bonifacio, D. Latawiec,R.H. Menk, F. Arfelli, S. Hüwel, G. Legname, H.J. Galla, S. Krol
Nanoscale 2, 2826 (2010).

Nanoparticulate Transport of Oximes over an In Vitro Blood-Brain Barrier Model
S. Wagner, J. Kufleitner, A. Zensi, M. Dadparvar, S. Wien, J. Bungert, T. Vogel, F. Worek, J. Kreuter, H. von Briesen
PLoS ONE 5, e14213 (2010).



Control of the blood-brain barrier by glucocorticoids and the cells of the neurovascular unit
S. Kröll, J. El-Gindi, G. Thanabalasundaram, P. Panpumthong, S. Schrot, C. Hartmann, H.J. Galla
Ann. N.Y. Acad. Sci. 1165, 228 (2009).

Closing the gap between the in-vivo and in-vitro blood–brain barrier tightness
K.C.-K. Malina, I. Cooper, V.I. Teichberg
Brain Res. 1284, 12 (2009).

Regulation of major efflux transporters under inflammatory conditions at the blood brain barrier in vitro
M. von Wedel-Parlow, P. Wölte, H.J. Galla
J. Neurochem. 111, 111 (2009).