The cellZscopeE is our entry model for automated TER measurement under physiological conditions. Main features are:
- Automatic determination of TER
- Full compatibilty with a broad range of standard cell culture inserts
- Cell Module can be loaded with 6 inserts simultaneously
- Time resolution per well: 1 datapoint/hour
- Upgrade to cellZscope+ possible
The cellZscopeE is the ideal entry-level system for computer-controlled TER (transepithelial / -endothelial resistance) measurements. TER of the cell layers under investigation is determined in real-time. Reliable long term measurements over days and weeks can be carried out.
The convincing performance and instrument operations and easy maintenance make the cellZscopeE the ideal tool for controlling the confluence of cell layers as well as for studying the influence of substances on the barrier function. It sweeps over a wide frequency range instead of simply measuring at a very few frequency points. This ensures a reliable and unambiguous detection of cell layer properties.
The innovative design of the cellZscopeE provides investigators full apical and basolateral access to all wells. Even without the user has to fully open the cell module. An aperture in the cover gives access to the inner and outer compartment of each well. Medium can easily be exchanged and substances added with a pipette.
Single-piece stainless steel “pots” serve as bottom electrodes, as vessels for holding the cell culture medium, and as supports for cell culture inserts.
The lid is made of highest quality stainless steel not only providing superior durability but also excellent compatibility with all standard cleaning and sterilization methods. The bottom electrodes can be detached easily without the use of tools. These features make the cellZscope systems a snap to clean and sterilize.
Three well sizes are available for use with small (“24-well” type), mid-sized (“12-well” type), or large (“6-well” type) inserts, respectively.
Different sizes of cell culture inserts can be combined within a single Cell Module. Thus allowing the automated monitoring and direct comparison of the barrier properties of cell layers housed in up to three different sized cell culture inserts.
The cellZscope comes with customized software which provides full instrument control including user defined experiment setup and automated data acquisition. Furthermore, it features comprehensive tools for displaying and statistically analyzing data as well as printing and exporting results.
The user interface is geared to easy operation of the instrument. Main features are:
- Monitor results in real time,
- enter individual well descriptions and notes,
- log and annotate all experimental events.
The cellZscope software allows to monitor the
- transepithelial / -endothelial electric resistance TER
of the cell layer as easy readout parameter during the course of the experiment.
User-friendly functions for exporting cellZscope data into popular file formats are included, making seminar and manuscript preparations a breeze.
Compatible cell culture inserts
The cellZscopeE is compatible with a variety of standard cell culture inserts from different manufacturers. Three versions of the electrodes are available. They are tailored for use with small (“24-well” type), mid-sized (“12-well” type), or large (“6-well” type) inserts, respectively. Different well sizes can be combined within one Cell Module.
cellZscope is a registered trademark of nanoAnalytics GmbH. Corning, Transwell and Falcon are registered trademarks of Corning Inc. Greiner Bio-One is a registered trademark and ThinCert is a trademark of Greiner Bio-One GmbH. Millipore and Millicell are registered trademarks of Merck KGaA. Nunc is a trademark of Thermo Fisher Scientific Inc. All other brand or product names are trademarks or registered trademarks of their respective holders.
|Controller||26 cm × 6 cm × 27 cm
(10.2 in × 2.4 in × 10.6 in)
|Cell Module||18 cm × 15 cm × 7 cm
(7.1 in × 6.0 in × 2.8 in)
|Space required in incubator||26 cm × 20 cm × 9 cm
(10.2 in × 7.9 in × 3.6 in)
|Length||150 cm (59 in)|
|Cross section (W×T)||15 mm × 4 mm
(0.6 in × 0.16 in)
|Usually the ribbon cable can be simply fed through the front door of the incubator.|
|Frequency range||1 Hz to 100 kHz|
|Measurement time for 6 wells||~ 5 min|
|Time resolution per well||1 datapoint/hour|
|Number of wells||6|
|Power Supply||100 – 240 Vac; 0.8 A; 47 – 63 Hz|
|Minimum requirements for the control computer||- 1.0 GHz processor speed
- 1024 MB RAM
- USB 2.0 port
- 1024×768 display
|Compatible OS||Microsoft Windows® 7/8/10|