Wissenschaftliche Publikationen
zum Thema 'cellZscope':
2024
Hypoxia induced deregulation of sphingolipids in colon cancer is a prognostic marker for patient outcome
K. El Hindi, S. Brachtendorf, J. C. Hartel, Ch. Renné, K. Birod, K. Schilling, S. Labocha, D. Thomas, N. Ferreirós, L. Hahnefeld, E. Dorochow, D. Del Turco, T. Deller, K. Scholich, D. C. Fuhrmann, A. Weigert, B. Brüne, G. Geisslinger, I. Wittig, K.-H. Link, S. Grösch
Biochim. Biophys. Acta, Mol. Basis Dis. 1870, 166906 (2024). → doi: 10.1016/j.bbadis.2023.166906
2023
Surfactant Semiconductors as Trojan Horses in Cell-Membranes for On-Demand and Spatial Regulation of Oxidative Stress
M. Jaschke, M. Plenge, M. Kunkel, T. Lehrich, J. Schmidt, K. Stöckemann, D. Heinemann, S. Siroky, A. Ngezahayo, S. Polarz
Adv. Healthcare Mater. 12, 2202290 (2023). → doi: 10.1002/adhm.202202290
TGF-Beta Modulates the Integrity of the Blood Brain Barrier In Vitro, and Is Associated with Metabolic Alterations in Pericytes
L. Schumacher, R. Slimani, L. Zizmare, J. Ehlers, F. Kleine Borgmann, J. C. Fitzgerald, P. Fallier-Becker, A. Beckmann, A. Grißmer, C. Meier, A. El-Ayoubi, K. Devraj, M. Mittelbronn, Ch. Trautwein, U. Naumann
Biomedicines 11, 214 (2023). → doi: 10.3390/biomedicines11010214
Synergistic induction of blood-brain barrier properties
G. Porkoláb, M. Mészáros, A. Szecskó, J. P. Vigh, F. R. Walter, R. Figueiredo, I. Kálomista, G. Vizsnyiczai, J.-S. Jan, F. Gosselet, M. Vastag, N. Hudson, M. Campbell, S. Veszelka, M. A. Deli
bioRxiv -, - (2023). → doi: 10.1101/2023.02.09.527899
Plasma of COVID-19 patients does not alter electrical resistance of human endothelial blood-brain barrier in vitro
A. Pociute, K. Kriauciunaite, A. Kaušyle, B. Zablockiene, T. Alcauskas, A. Jelinskaite, A. Rudenaite, L. Jancoriene, S. Rocka, A. Verkhratsky, A. Pivoriunas
bioRxiv -, - (2023). → doi: 10.1101/2023.09.28.559927
The neurovasculature as a target in temporal lobe epilepsy
Y. Reiss, S. Bauer, B. David, K. Devraj, E. Fidan, E. Hattingen, S. Liebner, N. Melzer, S. G. Meuth, F. Rosenow, T. Rüber, L. M. Willems, K. H. Plate
Brain Pathology. 33, e13147 (2023). → doi: 10.1111/bpa.13147
Compromised Blood-Brain Barrier Junctions Enhance Melanoma Cell Intercalation and Extravasation
F. Saltarin, A. Wegmüller, L. Bejarano, E. S. Ildiz, P. Zwicky, A. Vianin, F. Spadin, K. Soukup, V. Wischnewski, B. Engelhardt, U. Deutsch, I. J. Marques, M. Frenz, J. A. Joyce, R. Lyck
Cancers 15, 5071 (2023). → doi: 10.3390/cancers15205071
A Perfused In Vitro Human iPSC-Derived Blood–Brain Barrier Faithfully Mimics Transferrin Receptor-Mediated Transcytosis of Therapeutic Antibodies
F. Burgio, C. Gaiser, K. Brady, V. Gatta, R. Class, R. Schrage, L. Suter-Dick
Cell. Mol. Neurobiol. tba, tba (2023). → doi: 10.1007/s10571-023-01404-x
Recent advances in sensor-integrated brain-on-a-chip devices for real-time brain monitoring
C. Zhao, Z. Wang, X. Tang, J. Qin, Z. Jiang
Colloids Surf., B 229, 113431 (2023). → doi: 10.1016/j.colsurfb.2023.113431
Mouse embryonic stem cell-derived blood-brain barrier model: applicability to studying antibody triggered receptor mediated transcytosis
A. Jezierski, J. Huang, A. S. Haqqani, J. Haukenfrers, Z. Liu, E. Baumann, C. Sodja, C. Charlebois, C. E. Delaney, A. T. Star, Q. Liu, D. B. Stanimirovic
Fluids Barriers CNS 20, 36 (2023). → doi: 10.1186/s12987-023-00437-0
Epithelium dynamics differ in time and space when exposed to the permeation enhancers penetramax and EGTA. A head-to-head mechanistic comparison
D. A. Panou, S. F. Pedersen, M. Kristensen, H. M. Nielsen
Front. Drug Deliv. 3, 1221628 (2023). → doi: 10.3389/fddev.2023.1221628
Endothelial Protein kinase D1 is a major regulator of post-traumatic hyperinflammation
J. Schönfelder, T. Seibold, M. Morawe, R. Sroka, N. Schneider, J. Cai, J. Golomejic, L. Schütte, M. Armacki, M. Huber-Lang, M. Kalbitz, T. Seufferlein, T. Eiseler
Front. Immunol. 14, 1093022 (2023). → doi: 10.3389/fimmu.2023.1093022
Functional and molecular characterization of the Atlantic salmon gill epithelium cell line ASG-10; a tool for in vitro gill research
O. Slattery, M. K. Dahle, A. Y. M. Sundaram, B. F. Nowak, M. C. Gjessing, A. Solhaug
Front. Mol. Biosci. 10, 1242879 (2023). → doi: 10.3389/fmolb.2023.1242879
Transplacental passage of hyperforin, hypericin, and valerenic acid
D. Spiess, V. F. Abegg, A. Chauveau, J. Rath, A. Treyer, M. Reinehr, S. Kuoni, M. Oufir, O. Potterat, M. Hamburger, A. P. Simões-Wüst
Front. Pharmacol. 14, 1123194 (2023). → doi: 10.3389/fphar.2023.1123194
Optimization of Primary Human Bronchial Epithelial 3D Cell Culture with Donor-Matched Fibroblasts and Comparison of Two Different Culture Media
J. Maurer, T. Walles, C. Wiese-Rischke
Int. J. Mol. Sci. 24, 4113 (2023). → doi: 10.3390/ijms24044113
The Antimicrobial Peptide AMP-IBP5 Suppresses Dermatitis-like Lesions in a Mouse Model of Atopic Dermatitis through the Low-Density Lipoprotein Receptor-Related Protein-1 Receptor
H. L. T. Nguyen, G. Peng, J. V. Trujillo-Paez, H. Yue, R. Ikutama, M. Takahashi, Y. Umehara, K. Okumura, H. Ogawa, S. Ikeda, F. Niyonsaba
Int. J. Mol. Sci. 24, 5200 (2023). → doi: 10.3390/ijms24065200
Antibody-mediated inhibition of tissue-type plasminogen activator binding to the low-density lipoprotein receptor-related protein 1 as a potential beneficial modulator for stroke therapy
P. H. Klecker, L. Fritzen, A. D. Mazura, S. Weggen, C. U. Pietrzik
J. Cell. Biochem. 124, 1040 (2023). → doi: 10.1002/jcb.30431
Cathelicidin LL-37 Activates Human Keratinocyte Autophagy through the P2X7, Mechanistic Target of Rapamycin, and MAPK Pathways
R. Ikutama, G. Peng, S. Tsukamoto, Y. Umehara, J. V. Trujillo-Paez, H. Yue, H. L. T. Nguyen, M. Takahashi, S. Kageyama, M. Komatsu, K. Okumura, H. Ogawa, S. Ikeda, F. Niyonsaba
J. Invest. Dermatol. 143, 751 (2023). → doi: 10.1016/j.jid.2022.10.020
Measuring Changes in Brain Endothelial Barrier Integrity with Two Impedance-based Biosensors in Response to Cancer Cells and Cytokines
A. Anchan, J. J. W. Hucklesby, E. S. Graham, C. E. Angel
J. Vis. Exp. 199, e65959 (2023). → doi: 10.3791/65959
Mechanism and intervention of murine transfusion-related acute lung injury caused by anti-CD36 antibodies
D.-W. Chen, T. Kang, X.-Z. Xu, W.-J. Xia, X. Ye, Y.-B. Wu, Y.-R. Xu, J. Liu, H. Ren, J. Deng, Y.-K. Chen, H.-Q. Ding, M. Aslam, W. M. Zelek, B. P. Morgan, R. Kapur, S. Santoso, Y.-S. Fu
JCI Insight 8, e165142 (2023). → doi: 10.1172/jci.insight.165142
The Early Life Microbiota Is Not a Major Factor Underlying the Susceptibility to Postweaning Diarrhea in Piglets
M. Beaumont, C. Lencina, A. Bertide, L. Gallo, C. Barilly, C. Marrauld, L. Cauquil, A. Samson, S. Combes
Microbiol. Spectrum 11, e00694-23 (2023). → doi: 10.1128/spectrum.00694-23
Stereochemistry and Intermolecular Interactions Influence Carrier Peptide-Mediated Insulin Delivery
R. G. Diedrichsen, P. S. Tuelung, V. Foderà, H. M. Nielsen
Mol. Pharmaceutics 20, 1202 (2023). → doi: 10.1021/acs.molpharmaceut.2c00883
Claudin-23 reshapes epithelial tight junction architecture to regulate barrier function
A. Raya-Sandino, K. M. Lozada-Soto, N. Rajagopal, V. Garcia-Hernandez, A.-C. Luissint, J. C. Brazil, G. Cui, M. Koval, Ch. A. Parkos, S. Nangia, A. Nusrat
Nat. Commun. 14, 6214 (2023). → doi: 10.1038/s41467-023-41999-9
A hydrogel model of the human blood-brain barrier using differentiated stem cells
N. R. Singh, R. Gromnicova, A. Brachner, I. Kraev, I. A. Romero, W. Neuhaus, D. Male
PLoS One 18, e0283954 (2023). → doi: 10.1371/journal.pone.0283954
Glucuronoxylomannan intranasal challenge prior to Cryptococcus neoformans pulmonary infection enhances cerebral cryptococcosis in rodents
H. H. Lee, D. J. Carmichael, V. Ríbeiro, D. N. Parisi, M. E. Munzen, C. L. Charles-Niño, M. F. Hamed, E. Kaur, A. Mishra, J. Patel, R. B. Rooklin, A. Sher, M. A. Carrillo-Sepulveda, E. A. Eugenin, M. R. Dores, L. R. Martinez
PLoS Pathog. 19, e1010941 (2023). → doi: 10.1371/journal.ppat.1010941
Enhanced pathogenicity of Th17 cells due to natalizumab treatment: Implications for MS disease rebound
C. Janoschka, M. Lindner, N. Koppers, L. Starost, M. Liebmann, M. Eschborn, T. Schneider-Hohendorf, F. Windener, D. Schafflick, A.-K. Fleck, K. Koch, M. Deffner, A.-S. Schwarze, A. Schulte-Mecklenbeck, I. Metz, S. G. Meuth, C. C. Gross, G. Meyer zu Hörste, N. Schwab, T. Kuhlmann, H. Wiendl, M. Stoll, L. Klotz
PNAS 120, e2209944120 (2023). → doi: 10.1073/pnas.2209944120
TNFa induced by DNA-sensing in macrophage compromises retinal pigment epithelial (RPE) barrier function
M. Twarog, J. Schustak, Y.Y. Xu, M. Coble, K. Dolan, R. Esterberg, Q. Huang, M. Saint-Geniez, Y. Bao
Sci. Rep. 13, 14451 (2023). → doi: 10.1038/s41598-023-41610-7
Engineered apoptotic bodies hitchhiking across the blood-brain barrier achieved a combined photothermal-chemotherapeutic effect against glioma
Y. Liu, D. Hu, D. Gao, P. Gong, H. Zheng, M. Sun, Z. Sheng
Theranostics 13, 2966 (2023). → doi: 10.7150/thno.80632
2022
Profling the neurovascular unit unveils detrimental efects of osteopontin on the blood–brain barrier in acute ischemic stroke
D. Spitzer, S. Guérit, T. Puetz, M.I. Khel, M. Armbrust, M. Dunst, J. Macas, J. Zinke, G. Devraj, X. Jia, F. Croll, K. Sommer, K. Filipski, T.M. Freiman, M. Looso, S. Günther, M. Di Tacchio, K.-H. Plate, Y. Reiss, S. Liebner, P.N. Harter, K. Devraj
Acta Neuropathol. 144, 305 (2022). → doi: 10.1007/s00401-022-02452-1
Investigation of Host–Microbe–Parasite Interactions in an In Vitro 3D Model of the Vertebrate Gut
Ch.-M. Moysidou, A.M. Withers, A.J. Nisbet, D.R.G. Price, C.E. Bryant, C. Cantacessi, R.M. Owens
Adv. Biol. 6, 2200015 (2022). → doi: 10.1002/adbi.202200015
Reversing Aß Fibrillation and Inhibiting Aß Primary Neuronal Cell Toxicity Using Amphiphilic Polyphenylene Dendrons
S. Xiang, J. Wagner, T. Lückerath, K. Müllen, D.Y.W. Ng, J. Hedrich, T. Weil
Adv. Healthc. Mater. 11, e2101854 (2022). → doi: 10.1002/adhm.202101854
A Biomicrofluidic Screening Platform for Dysfunctional Endothelium-Targeted Nanoparticles and Therapeutics
S. Bazban-Shotorbani, F. Gavins, K. Kant, M. Dufva, N. Kamaly
Adv. NanoBiomed Res. 2, 2100092 (2022). → doi: 10.1002/anbr.202100092
Serially passaged, conditionally reprogrammed nasal epithelial cells as a model to study epithelial functions and SARS-CoV-2 infection
H. Schmidt, L. Gutjahr, A. Sauter, F. Zech, R. Nchioua, S. Stenger, M. Frick, F. Kirchhoff, P. Dietl, O.H. Wittekindt
Am. J. Physiol. 322, C591 (2022). → doi: 10.1152/ajpcell.00363.2021
Changes in transepithelial electrical resistance and intracellular ion concentration in TGF-ß-induced epithelial-mesenchymal transition of retinal pigment epithelial cells
Minli Wang, Jiayi Wei, Hui Li, Fang Wang
Am. J. Transl. Res. 14, 2728 (2022).
Evaluation of Caco-2 and human intestinal epithelial cells as in vitro models of colonic and small intestinal integrity
S. Lopez-Escaleram, A. Wellejus
Biochem. Biophys. Rep. 31, 101314 (2022). → doi: 10.1016/j.bbrep.2022.101314
Melanoma Mediated Disruption of Brain Endothelial Barrier Integrity Is Not Prevented by the Inhibition of Matrix Metalloproteinases and Proteases
A. Anchan, G. Finlay, C.E. Angel, J.J.W. Hucklesby, E.S. Graham
Biosensors 12, 660 (2022). → doi: 10.3390/bios12080660
Activation of non-classical NMDA receptors by glycine impairs barrier function of brain endothelial cells
L. Epping, Ch.B. Schroeter, Ch. Nelke, S. Bock, L. Gola, N. Ritter, A.M. Herrmann, S. Räuber, A. Henes, B. Wasser, J. Fernandez-Orth, W. Neuhaus, S. Bittner, T. Budde, M. Platten, S. Kovac, G. Seebohm, T. Ruck, M. Cerina, S.G. Meuth
Cell. Mol. Life Sci. 79, 479 (2022). → doi: 10.1007/s00018-022-04502-z
PCSK9 acts as a key regulator of Aß clearance across the blood–brain barrier
A.D. Mazura, A. Ohler, St.E. Storck, M. Kurtyka, F. Scharfenberg, S. Weggen, Ch. Becker-Pauly, C.U. Pietrzik
Cell. Mol. Life Sci. 79, 212 (2022). → doi: 10.1007/s00018-022-04237-x
Intestinal Epithelial AMPK Deficiency Causes Delayed Colonic Epithelial Repair in DSS-Induced Colitis
S. Olivier, H. Diounou, C. Pochard, L. Frechin, E. Durieu, M. Foretz, M. Neunlist, M. Rolli-Derkinderen, B. Viollet
Cells 11, 590 (2022). → doi: 10.3390/cells11040590
Polyubiquitination and SUMOylation Sites Regulate the Stability of ZO-2 Protein and the Sealing of Tight Junctions
M. Cano-Cortina, L. Alarcón, J. Miranda, O. Huber, L. González-Mariscal
Cells 11, 3296 (2022). → doi: 10.3390/cells11203296
Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier
J. W. Shin, S. An, D. Kim, H. Kim, J. Ahn, J. Eom, W. K. You, H. Yun, B. Lee, B. Sung, J. Jung, S. Kim, Y. Son, E. Sung, H. Lee, S. Lee, D. Song, Y. Pak, J. K. Sandhu, A. S. Haqqani, D. B. Stanimirovic, J. Yoo, D. Kim, S. Maeng, J. Lee, S. H. Lee
Cells Rep. Methods 2, 100338 (2022). → doi: 10.1016/j.crmeth.2022.100338
Hexafluoroisopropyl Carbamates as Selective MAGL and Dual MAGL/FAAH Inhibitors: Biochemical and Physicochemical Properties
M. Barth, S. Rudolph, J. Kampschulze, I. Meyer zu Vilsendorf, W. Hanekamp, D. Mulac, K. Langer, M. Lehr
ChemMedChem 17, e202100757 (2022). → doi: 10.1002/cmdc.202100757
Photoactive surfactant semiconductors characterized by a dissociative identity disorder integrated into the membranes of living cells as trojan horses for on-demand and spatial regulation of oxidative stress
M. Jaschke, M. Plenge, M. Kunkel, T. Lehrich, J. Schmidt, K. Stöckemann, D. Heinemann, S. Siroky, A. Ngezahay, S. Polarz
ChemRxiv -, - (2022). → doi: 10.26434/chemrxiv-2022-587qb
GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression
V. Königs, S. Pierre, M. Schicht, J. Welss, L. Hahnefeld, V. Rimola, E. Lütjen-Drecoll, G. Geisslinger, K. Scholich
Diabetes 71, 774 (2022). → doi: 10.2337/db21-0711
Roles of Transepithelial Electrical Resistance in Mechanisms of Retinal Pigment Epithelial Barrier and Retinal Disorders
M. Wang, H. Li, F. Wang
Discov. Med. 34, 171 (2022).
Re-evaluation of the hCMEC/D3 based in vitro BBB model for ABC transporter studies
V. Balzer, P. Poc, E. Puris, S. Martin, M. Aliasgari, S. Aurio, G. Fricker
Eur. J. Pharm. Biopharm. 173, 12 (2022). → doi: 10.1016/j.ejpb.2022.02.017
Highly cationic cell-penetrating peptides affect the barrier integrity and facilitates mannitol permeation in a human stem cell-based blood-brain barrier model
P. Frøslev, H. Franzyk, B. Ozgür, B. Brodin, M. Kristensen
Eur. J. Pharm. Sci. 168, 106054 (2022). → doi: 10.1016/j.ejps.2021.106054
Application of blood brain barrier models in pre-clinical assessment of glioblastoma-targeting CAR-T based immunotherapies
J. Huang, Y.B. Li, C. Charlebois, T. Nguyen, Z. Liu, D. Bloemberg, A. Zafer, E. Baumann, C. Sodja, S. Leclerc, G. Fewell, Q. Liu, B. Prabhakarpandian, S. McComb, D.B. Stanimirovic, A. Jezierski
Fluids Barriers CNS 19, 38 (2022). → doi: 10.1186/s12987-022-00342-y
The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood–Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood–Brain Barrier In Vitro and In Vivo
E.L. Al Humaidan, S.L. Pedersen, A. Burkhart, Ch.L.M. Rasmussen, T. Moos, P. Fuchs, E.F.A. Fernandes, B. Ozgür, K. Strømgaard, A. Bach, B. Brodin, M. Kristensen
Front. Drug Deliv. 2, 854703 (2022). → doi: 10.3389/fddev.2022.854703
The pore-forming subunit C2IIa of the binary clostridium botulinum C2 toxin reduces the chemotactic translocation of human polymorphonuclear leukocytes
J. Eisele, S. Schreiner, J. Borho, S. Fischer, S. Heber, S. Endres, M. Fellermann, L. Wohlgemuth, M. Huber-Lang, G. Fois, M. Fauler, M. Frick, H. Barth
Front. Pharmacol. 13, 810611 (2022). → doi: 10.3389/fphar.2022.810611
T-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model
K. El-Hindi, S. Brachtendorf, J.C. Hartel, S. Oertel, K. Birod, N. Merz, S. Trautmann, D. Thomas, A. Weigert, T.J. Schäufele, K. Scholich, S. Schiffmann, T. Ulshöfer, O. Utermöhlen, S. Grösch
Int. J. Mol. Sci. 23, 1866 (2022). → doi: 10.3390/ijms23031866
Differences and interactions in placental manganese and iron transfer across an in vitro model of human villous trophoblasts
V. Michaelis, L. Aengenheister, M. Tuchtenhagen, J. Rinklebe, F. Ebert, T. Schwerdtle, T. Buerki-Thurnherr, J. Bornhorst
Int. J. Mol. Sci. 23, 3296 (2022). → doi: 10.3390/ijms23063296
Hypomethylation of CLDN4 Gene Promoter Is Associated with Malignant Phenotype in Urinary Bladder Cancer
F. Maesaka, M. Kuwada, S. Horii, S. Kishi, R. Fujiwara-Tani, S. Mori, K. Fujii, T. Mori, H. Ohmori, T. Owari, M. Miyake, Y. Nakai, N. Tanaka, U.K. Bhawal, Y. Luo, M. Kondoh, K. Fujimoto, H. Kuniyasu
Int. J. Mol. Sci. 23, 6516 (2022). → doi: 10.3390/ijms23126516
Experimental and Clinical Evidence Suggests That Treatment with Betacellulin Can Alleviate Th2-Type Cytokine-Mediated Impairment of Skin Barrier Function
G. Peng, S. Tsukamoto, Y. Umehara, R. Kishi, M. Tominaga, K. Takamori, K. Okumura, H. Ogawa, S. Ikeda, F. Niyonsaba
Int. J. Mol. Sci. 23, 11520 (2022). → doi: 10.3390/ijms231911520
Intestinal Absorption and Metabolism of the Tomato Imidazole Alkaloids N-Caprylhistamine-ß-glucoside and N-Caprylhistamine
M. Kasimir, M. Hahn, I. Westkamp, A. Karentzopoulos, M. Behrens, Y. Hövelmann, H.-U. Humpf
J. Agric. Food Chem. 70, 1526 (2022). → doi: 10.1021/acs.jafc.1c08047
Exploring lipophilic compounds that induce BDNF secretion in astrocytes beyond the BBB using a new multi-cultured human in vitro BBB model
M. Fujisawa, Y. Takeshita, S. Fujikawa, K. Matsuo, M. Okamoto, M. Tamada, F. Shimizu, Y. Sano, M. Koga, T. Kanda
J. Neuroimmunol. 362, 577783 (2022). → doi: 10.1016/j.jneuroim.2021.577783
Endothelial Sphingosine-1-Phosphate Receptor 4 Regulates Blood-Brain Barrier Permeability and Promotes a Homeostatic Endothelial Phenotype
L. Hansen, N. Lohfink, R. Vutukuri, R.-I. Kestner, S. Trautmann, M. Hecht, P.V. Wagner, D. Spitzer, M.I. Khel, J. Macas, N. Ferreirós, R. Gurke, S. Günther, W. Pfeilschifter, K. Devraj
J. Neurosci. 42, 1908 (2022). → doi: 10.1523/JNEUROSCI.0188-21.2021
Human ß-defensin-3 attenuates atopic dermatitis–like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway
G. Peng, S. Tsukamoto, R. Ikutama, H.L.T. Nguyen, Y. Umehara, J.V. Trujillo-Paez, H. Yue, M. Takahashi, T. Ogawa, R. Kishi, M. Tominaga, K. Takamori, J. Kitaura, S. Kageyama, M. Komatsu, K. Okumura, H. Ogawa, S. Ikeda, F. Niyonsaba
J. Clin. Invest. 132, e156501 (2022). → doi: 10.1172/JCI156501
TRPV4 Stimulation Level Regulates Ca2+-Dependent Control of Human Corneal Endothelial Cell Viability and Survival
J. Donau, H. Luo, I. Virta, A. Skupin, M. Pushina, J. Loeffler, F.V. Haertel, A. Das, T. Kurth, M. Gerlach, D. Lindemann, P.S. Reinach, S. Mergler 3, M. Valtink
Membranes 12, 281 (2022). → doi: 10.3390/membranes12030281
Roseburia intestinalis Modulates PYY Expression in a New a Multicellular Model including Enteroendocrine Cells
T. Gautier, N. Fahet, Z. Tamanai-Shacoori, N. Oliviero, M. Blot, A. Sauvager, A. Burel, S. David-Le Gall, S. Tomasi, S. Blat, L. Bousarghin
Microorganisms 11, 2263 (2022). → doi: 10.3390/microorganisms10112263
Human Milk Oligosaccharides and Lactose Differentially Affect Infant Gut Microbiota and Intestinal Barrier In Vitro
J.M. Natividad, B. Marsaux, C.L.G. Rodenas, A. Rytz, G. Vandevijver, M. Marzorati, P. Van den Abbeele, M. Calatayud, F. Rochat
Nutrients 14, 2546 (2022). → doi: 10.3390/nu14122546
In Vitro–In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier
L. Kovar, L. Wien, D. Selzer, Y. Kohl, R. Bals, T. Lehr
Pharmaceuticals 15, 250 (2022). → doi: 10.3390/ph15020250
Experimental Comparison of Primary and hiPS-Based In Vitro Blood–Brain Barrier Models for Pharmacological Research
K. Danz, T. Höcherl, S.L. Wien, L. Wien, H. von Briesen, S. Wagner
Pharmaceutics 14, 703 (2022). → doi: 10.3390/pharmaceutics14040737
Electrospun Scaffolds as Cell Culture Substrates for the Cultivation of an In Vitro Blood–Brain Barrier Model Using Human Induced Pluripotent Stem Cells
F. Rohde, K. Danz, N. Jung, S. Wagner, M. Windbergs
Pharmaceutics 14, 1308 (2022). → doi: 10.3390/pharmaceutics14061308
In Vitro Models of the Blood–Cerebrospinal Fluid Barrier and Their Applications in the Development and Research of (Neuro)Pharmaceuticals
F. Dabbagh, H. Schroten, Ch. Schwerk
Pharmaceutics 14, 1729 (2022). → doi: 10.3390/pharmaceutics14081729
The Bioactive Phenolic Agents Diaryl Ether CVB2-61 and Diarylheptanoid CVB4-57 as Connexin Hemichannel Blockers
A. Dierks, C. Vanucci-Bacqué, A.-M. Schäfer, T. Lehrich, F. Ruhe, P. Schadzek, F. Bedos-Belval, A. Ngezahayo
Pharmaceutics 15, 1173 (2022). → doi: 10.3390/ph15101173
Permeability of dopamine D2 receptor agonist hordenine across the intestinal and blood-brain barrier in vitro
M. Hahn, V. Lindemann, M. Behrens, D. Mulac, K. Langer, M. Esselen, H.-U. Humpf
PLoS One 17, e0269486 (2022). → doi: 10.1371/journal.pone.0269486
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Thermo-responsive cell culture carriers based on poly(vinyl methyl ether)—the effect of biomolecular ligands to balance cell adhesion and stimulated detachment
J. Teichmann, M. Nitschke, D. Pette, M. Valtink, S. Gramm, F.V. Härtel, T. Noll, R.H.W. Funk, K. Engelmann, C. Werner
Sci. Technol. Adv. Mater. 16, 45003 (2016).
Human Alpha-Defensin HNP1 Increases HIV Traversal of the Epithelial Barrier: A Potential Role in STI-Mediated Enhancement of HIV Transmission
K. Valere, A. Rapista, E. Eugenin, W. Lu, T.L. Chang
Viral Immunol. 28, 609 (2016).
2015
Transport of treosulfan and temozolomide across an in-vitro blood-brain barrier model
U. Linz, M. Hupert, B. Santiago-Schübel, S. Wien, J. Stab, S. Wagner
Anticancer Drugs 26, 728 (2015).
Organic electrochemical transistors for cell-based impedance sensing
J. Rivnay, M. Ramuz, P. Leleux, A. Hama, M. Huerta, R.M. Owens
Appl. Phys. Lett. 106, 43301 (2015).
Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers
C. Staat, C. Coisne, S. Dabrowski, S.M. Stamatovic, A.V. Andjelkovic, H. Wolburg, B. Engelhardt, I.E. Blasig
Biomaterials 54, 9 (2015).
Live Faecalibacterium prausnitzii in an apical anaerobic model of the intestinal epithelial barrier
D. Ulluwishewa, R.C. Anderson, W. Young, W.C. McNabb, P. van Baarlen, P.J. Moughan, J.M. Wells, N.C. Roy
Cell Microbiol. 17, 226 (2015).
Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier
M. Abadier, J. Haghayegh Jahromi, L. Cardoso Alves, R. Boscacci, D. Vestweber, S. Barnum, U. Deutsch, B. Engelhardt, R. Lyck
Eur. J. Immunol. 45, 1043 (2015).
Expression of the ALS-causing variant hSOD1G93A leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood–spinal cord barrier model
S. Meister, S. Storck, E. Hameister, C. Behl, S. Weggen, A. Clement, C. Pietrzik
J. Cereb. Blood Flow Metab. 35, 1112 (2015).
Nanotoxicity of poly(n-butylcyano-acrylate) nanoparticles at the blood–brain barrier, in human whole blood and in vivo
M. Kolter , M. Ott, C. Hauer, I. Reimold, G. Fricker
J. Control Release 197, 165 (2015).
Irsogladine Maleate Regulates Gap Junctional Intercellular Communication-Dependent Epithelial Barrier in Human Nasal Epithelial Cells
R. Miyata, K. Nomura, T. Kakuki, K. Takano, T. Kohno, T. Konno, N. Sawada, T. Himi, T. Kojima
J. Membr. Biol. 248, 327 (2015).
In Vitro Blood–Brain Barrier Models—An Overview of Established Models and New Microfluidic Approaches
A. Wolff, M. Antfolk, B. Brodin, M. Tenje
J. Pharm. Sci. 104, 2727 (2015).
Non-Saccharomyces yeasts protect against epithelial cell barrier disruption induced by Salmonella enterica subsp. enterica serovar Typhimurium
I.M. Smith, A. Baker, N. Arneborg, L. Jespersen
Lett. Appl. Microbiol. 61, 491 (2015).
The blood–cerebrospinal fluid barrier – first evidence for an active transport of organic mercury compounds out of the brain
H. Lohren, J. Bornhorst, H.J. Galla, T. Schwerdtle
Metallomics 7, 1420 (2015).
Arsenic-containing hydrocarbons and arsenic-containing fatty acids: Transfer across and presystemic metabolism in the Caco-2 intestinal barrier model
S. Meyer, G. Raber, F. Ebert, M.S. Taleshi, K.A. Francesconi, T. Schwerdtle
Mol. Nutr. Food Res. 59, 2044 (2015).
Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier
A. Bernd, M. Ott, H. Ishikawa, H. Schroten, C. Schwerk, G. Fricker
Pharm. Res. 32, 2973 (2015).
Claudin-4 binder C-CPE 194 enhances effects of anticanceragents on pancreatic cancer cell lines via a MAPK pathway
K. Tsuyoshi, K. Masuo, K. Daisuke, I. Tatsuya, K. Yasutoshi, I. Masafumi, K. Takayuki, K. Takumi, F. Tomohisa, S. Norimasa, H. Koichi, K. Takashi
Pharmacol. Res. Perspect. 3, e00196 (2015).
Intestinal formation of trans-crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier
M. Lautenschläger, J. Sendker, S. Hüwel, H.J. Galla, S. Brandt, M. Düfer, K. Riehemann, A. Hensel
Phytomed. 22, 36 (2015).
ANKS1B Interacts with the Cerebral Cavernous Malformation Protein-1 and Controls Endothelial Permeability but Not Sprouting Angiogenesis
S.E. Herberich, R. Klose, I. Moll, W.-J. Yang, J. Wüstehube-Lausch, A. Fischer
PLoS One 10, e0145304 (2015).
Blood-Brain Barrier Effects of the Fusarium Mycotoxins Deoxynivalenol, 3 Acetyldeoxynivalenol, and Moniliformin and Their Transfer to the Brain
M. Behrens, S. Hüwel, H.-J. Galla, H.-U. Humpf
PLoS One 10, e0143640 (2015).
Dynamic Regulation of a Cell Adhesion Protein Complex Including CADM1 by Combinatorial Analysis of FRAP with Exponential Curve-Fitting
M. Sakurai-Yageta, T. Maruyama, T. Suzuki, K. Ichikawa, Y. Murakami
PLoS One 10, e0116637 (2015).
Endothelial-Mesenchymal Transition of Brain Endothelial Cells: Possible Role during Metastatic Extravasation
I.A. Krizbai, Á. Gasparics, P. Nagyoszi, C. Fazakas, J. Molnár, I. Wilhelm, R. Bencs, L. Rosivall, A. Sebe
PLoS One 10, e0123845 (2015).
Chitosan encapsulation modulates the effect of capsaicin on the tight junctions of MDCK cells
M. Kaiser, S. Pereira, L. Pohl, S. Ketelhut, B. Kemper, C. Gorzelanny, H.J. Galla, B. M. Moerschbacher, F.M. Goycoolea
Sci. Rep. 5, 10048 (2015).
Using white noise to gate organic transistors for dynamic monitoring of cultured cell layers
J. Rivnay, P. Leleux, A. Hama, M. Ramuz, M. Huerta, G.G. Malliaras, R.M. Owens
Sci. Rep. 5, 11613 (2015).
Thermo-responsive cell culture carriers based on poly(vinyl methyl ether)—the effect of biomolecular ligands to balance cell adhesion and stimulated detachment
J. Teichmann, M. Nitschke, D. Pette, M. Valtink, S. Gramm, F.V. Härtel, T. Noll, R.H.W. Funk, K. Engelmann, C. Werner
Sci. Technol. Adv. Mater. 16, 45003 (2015).
Human Alpha-Defensin HNP1 Increases HIV Traversal of the Epithelial Barrier: A Potential Role in STI-Mediated Enhancement of HIV Transmission
K. Valere, A. Rapista, E. Eugenin, W. Lu, T.L. Chang
Viral Immunol. 28, 609 (2015).
2014
Dynamic Monitoring of Salmonella typhimurium Infection of Polarized Epithelia Using Organic Transistors
S.A. Tria, M. Ramuz, M. Huerta, P. Leleux, J. Rivnay, L.H. Jimison, A. Hama, G.G. Mall
Adv. Healthcare Mater. 3, 1053 (2014).
Highly Conserved Cysteines Are Involved in the Oligomerization of Occludin-Redox Dependency of the Second Extracellular Loop
Ch. Bellmann, S. Schreivogel, R. Günther, S. Dabrowski, M. Schümann, H. Wolburg, I.E. Blasig
Antioxid. Redox Signaling 20, 855 (2014).
Dietary Xylo-oligosaccharide stimulates intestinal bifidobacteria and lactobacilli but has limited effect on intestinal integrity in rats
E.G. Christensen, T.R. Licht, T.D. Leser, M.I. Bahl
BMC Res. Notes 7, 660 (2014).
The antimicrobial protein S100A7/psoriasin enhances theexpression of keratinocyte differentiation markers and strengthens the skin’s tight junction barrier
F. Hattori, C. Kiatsurayanon, K. Okumura, H. Ogawa, S. Ikeda, K. Okamoto, F. Niyonsaba
Br. J. Dermatol. 171, 742 (2014).
In Vitro Models of the Blood–Brain Barrier
C.J. Czupalla, S. Liebner, K. Devraj
Cerebral Angiogenesis Method Molec. Biol. 1135, 415 (2014). → doi: 10.1007/978-1-4939-0320-7_34
Differential apicobasal VEGF signaling at vascular blood-neural barriers
N. Hudson, M.B. Powner, M.H. Sarker, T. Burgoyne, M. Campbell, Z.K. Ockrim, R. Martinelli, C.E. Futter, M.B. Grant, P.A. Fraser, D.T. Shima, J. Greenwood, P. Turowski
Dev. Cell. 30, 541 (2014).
Freeze-drying of HI-6-loaded recombinant human serum albumin nanoparticles for improved storage stability
M. Dadparvar, S. Wagner, S. Wien, F. Worek, H. von Briesen, J. Kreuter
Euro. J. Pharm. Biopharm. 88, 510 (2014).
The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers
M.K. Nøhra, S.H. Hansena, B. Brodin, R. Holm, C.U. Nielsen
Euro. J. Pharm. Sci. 51, 1 (2014).
Increased Efflux of Amyloid-ß Peptides through the Blood-Brain Barrier by Muscarinic Acetylcholine Receptor Inhibition Reduces Pathological Phenotypes in Mouse Models of Brain Amyloidosis
P. Paganetti, K. Antoniello, K. Devraj, N. Toni, D. Kieran, R. Madani, M. Pihlgren, O. Adolfsson, W. Froestl, A. Schrattenholz, S. Liebner, D. Havas, M. Windisch, J.R. Cirrito, A. Pfeifer, A. Muhs
J. Alzheimer's Disease 38, 767 (2014).
Comprehensive Cysteine-Scanning Mutagenesis Reveals Claudin-2 Pore-Lining Residues with Different Intrapore Locations
J. Li, M. Zhuo, L. Pei, M. Rajagopa, A.S.L. Yu
J. Biol. Chem. 289, 6475 (2014).
Lipocalin-2 deficiency attenuates neuroinflammation and brain injury after transient middle cerebral artery occlusion in mice
M. Jin, J.-H. Kim, E. Jang, Y.M. Lee, H.S. Han, D.K. Woo, D.H. Park, H. Kook, K. Suk
J. Cereb. Blood Flow Metab. 34, 1306 (2014).
The Human Cathelicidin LL-37 Host Defense Peptide Upregulates Tight Junction-Related Proteins and Increases Human Epidermal Keratinocyte Barrier Function
T. Akiyama, F. Niyonsaba, Ch. Kiatsurayanon, T.T. Nguyen, H. Ushio, T. Fujimura, T. Ueno, K. Okumura, H. Ogawa, S. Ikeda
J. Innate Immun. 6, 739 (2014).
The M1 Protein of Streptococcus pyogenes Triggers an Innate Uptake Mechanism into Polarized Human Endothelial Cells
A. Ochel, M. Rohde, G.S. Chhatwal, S.R. Talay
J. Innate Immun. 6, 585 (2014).
Host Defense (Antimicrobial) Peptide, Human ß-Defensin-3, Improves the Function of the Epithelial Tight-Junction Barrier in Human Keratinocytes
C. Kiatsurayanon, F. Niyonsaba, R. Smithrithee, T. Akiyama, H. Ushio, M. Hara, K. Okumura, S. Ikeda, H. Ogawa
J. Invest. Dermatol. 134, 2163 (2014).
Synthesis and Pharmacological Evaluation of 5-Pyrrolidinylquinoxalines as a Novel Class of Peripherally Restricted ?-Opioid Receptor Agonists
C. Bourgeois, E. Werfel, F. Galla, K. Lehmkuhl, H. Torres-Gómez, D. Schepmann, B. Kögel, T. Christoph, W. Straßburger, W. Englberger, M. Soeberdt, S. Hüwel, H.-J. Galla, B. Wünsch
J. Med. Chem. 57, 6845 (2014).
PACAP Enhances Barrier Properties of Cerebral Microvessels
I. Wilhelm, C. Fazakas, A. Tamás, G. Tóth, D. Regl, I.A. Krizbai
J. Mol. Neurosci. 54, 469 (2014). → doi: 10.1007/s12031-014-0260-4
The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro
S. Cramer, S. Tacke, J. Bornhorst, J. Klingauf, T. Schwerdtle, H.-J. Galla
J. Nanomed. Nanotechnol. 5, 225 (2014).
Evaluation of Lignans from Heliopsis helianthoides var. scabra for Their Potential Antimetastatic Effects in the Brain
Z. Hajdu, J. Haskó, I.A. Krizbai, I. Wilhelm, N. Jedlinszki, C. Fazakas, J. Molnár, P. Forgo, J. Hohmann, D. Csupor
J. Nat. Prod. 77, 2641 (2014).
Development and validation of a LC–MS/MS method for assessment of an anti-inflammatory indolinone derivative by in vitro blood–brain barrier models
E.A. Jähne, D.E. Eigenmann, M. Culot, R. Cecchelli, F.R. Walter, M.A. Deli, R. Tremmel, G. Fricker, M. Smiesko, M. Hamburger, M. Oufir
J. Pharm. Biomed. Anal. 98, 235 (2014). → doi: 10.1016/j.jpba.2014.05.026
What Is the Mechanism Behind Increased Permeation Rate of a Poorly Soluble Drug from Aqueous Dispersions of an Amorphous Solid Dispersion?
K.J. Frank, U. Westedt, K.M. Rosenblatt, P. Hölig, J. Rosenberg, M. Mägerlein, G. Fricker, M. Brandl
J. Pharm. Sci. 103, 1779 (2014).
Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
S.A. Tria, M. Ramuz, L.H. Jimison, A. Hama, R.M. Owens
J. Visualized Exp. 84, e51102 (2014).
Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice
S.W. Park, J.H. Kim, I. Mook-Jung, K.-W. Kim, W.J. Park, K.H. Park, J.H. Kim
Neurobiol. Aging 35, 2013 (2014).
Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation
K. Ridder, S. Keller, M. Dams, A.-K. Rupp, J. Schlaudraff, D. Del Turco, J. Starmann, J. Macas, D. Karpova, K. Devraj, C. Depboylu, B. Landfried, B. Arnold, K.H. Plate, G. Höglinger, H. Sültmann, P. Altevogt, S. Momma
PLoS Biol. 12, e1001874 (2014).
Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells.
K. Nomura, K. Obata, T. Keira, R. Miyata, S. Hirakawa, K. Takano, T. Kohno, N. Sawada, T. Himi, T. Kojima
Respir. Res. 15, 21 (2014).
2013
Nanoparticulate flurbiprofen reduces amyloid-ß42 generation in an in vitro blood–brain barrier model
S. Meister, I. Zlatev, J. Stab, D. Docter, S. Baches, R.H. Stauber, M. Deutsch, R. Schmidt, S. Ropele, M. Windisch, K. Langer, S. Wagner, H. von Briesen, S. Weggen, C.U. Pietrzik
Alzheimer's Res. Ther. 5, 51 (2013).
Validation of the organic electrochemical transistor for in vitro toxicology
S. Tria, L.H. Jimison, A. Hama, M. Bongo, R.M. Owens
Biochim. Biophys. Acta 1830, 4381 (2013).
Sensing of EGTA Mediated Barrier Tissue Disruption with an Organic Transistor
S. Tria, L.H. Jimison, A. Hama, M. Bongo, R.M. Owens
Biosen. 3, 44 (2013).
Vectorial secretion of interleukin-8 mediates autocrine signalling in intestinal epithelial cells via apically located CXCR1
O. Rossi , J. Karczewski, E.H. Stolte, R.J.M. Brummer, M.A. van Nieuwenhoven, M. Meijerink, J.R.J. van Neerven, S.C.D. van Ijzendoorn, P. van Baarlen, J.M. Wells
BMC Res. Notes 6, 431 (2013).
Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro
C.U. Nielsen, S. Frølund, S. Abdulhadi, H. Sari, L. Langthaler, M.K. Nøhr, M.A. Kall, B. Brodin, R. Holm
Br. J. Pharmacol. 170, 1041 (2013).
Constitutive androstane receptor upregulates Abcb1 and Abcg2 at the blood–brain barrier after CITCO activation
J. Lemmen, I.E.P. Tozakidis, P. Bele, H.J. Galla
Brain Res. 1501, 68 (2013).
Pregnane X receptor upregulates ABC-transporter Abcg2 and Abcb1 at the blood-brain barrier
J. Lemmen, I.E.P. Tozakidis, H.J. Galla
Brain Res. 1491, 1 (2013).
Acetaminophen Changes Intestinal Epithelial Cell Membrane Properties, Subsequently Affecting Absorption Processes
C. Schäfer, K.R. Schröder, O. Höglinger, S. Tollabimazraehno, M.R. Lornejad-Schäfer
Cell Physiol. Biochem. 32, 431 (2013).
Regulation of tight junctions by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano
M. Someya, T. Kojima, M. Ogawa, T. Ninomiya, K. Nomura, A. Takasawa, M. Murata, S. Tanaka, T. Saito, N. Sawada
Cell Tissue Res. 354, 481 (2013).
Physicochemical characterization and in vitro permeation of an indirubin derivative
N. Heshmati, B. Wagner, X. Cheng, T. Scholz, M. Kansy, G. Eisenbrand, G. Fricker
Eur. J. Pharm. Sci. 50, 467 (2013).
Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood-brain barrier model for drug permeability studies
D.E. Eigenmann, G. Xue, K.S. Kim KS, A.V. Moses, M. Hamburger, M. Oufir
Fluids Barriers CNS 10, 33 (2013). → doi: 10.1186/2045-8118-10-33
Impedance-based cell monitoring: barrier properties and beyond
K. Benson, S. Cramer, H.J. Galla
Fluids Barriers CNS 10, 5 (2013).
Expression of Shiga toxin 2e glycosphingolipid receptors of primary porcine brain endothelial cells and toxin-mediated breakdown of the blood-brain barrier
I. Meisen, R. Rosenbrück, H.J. Galla, S. Hüwel, I.U. Kouzel, M. Mormann, H. Karch, J. Müthing
Glycobiol. 23, 745 (2013).
Transepithelial permeability studies of flavan-3-ol-C-glucosides and procyanidin dimers and trimers across the Caco-2 cell monolayer
S. Hemmersbach, S.S. Brauer, S. Hüwel, H.J. Galla, H.U. Humpf
J. Agric. Food Chem. 61, 7932 (2013).
The biocompatibility of a polyelectrolyte vitreous body substitute on a high resistance in vitro model of the blood-retinal barrier
F. Strotmann, I. Wolf, H.-J. Galla
J. Biomater. Appl. 28, 334 (2013).
The cytokine response of U937-derived macrophages infected through antibody dependent enhancent of dengue virus disrupts cell apical junctional complexes and increase vascular permeability
H. Puerta-Guardo, A. Raya-Sandino, L. González-Mariscal, V.H. Rosales, J. Ayala-Dávila, B. Chávez-Mungía, D. Martínez-Fong, F. Medina, J.E. Ludert, R. María del Angel
J. Virol. 87, 7486 (2013).
In vitro intestinal bioavailability of arsenosugar metabolites and presystemic metabolism of thio-dimethylarsinic acid in Caco-2 cells
L. Leffers, C.A. Wehe, S. Hüwel, M. Bartel, F. Ebert, M.S. Taleshi, H.-J. Galla, U. Karst, K.A. Francesconie, T. Schwerdtle
Metallomics 5, 1031 (2013).
In vitro toxicological characterization of two arsenosugars and their metabolites
L. Leffers, F. Ebert, M.S. Taleshi, K.A. Francesconi, T. Schwerdtle
Mol. Nutr. Food Res. 57, 1270 (2013).
Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS
S. Bittner, T. Ruck, M.K. Schuhmann, A.M. Herrmann, H. Moha ou Maati, N. Bobak, K. Göbel, F. Langhauser, D. Stegner, P. Ehling, M. Borsotto, H.-C. Pape, B. Nieswandt, C. Kleinschnitz, C. Heurteaux, H.-J. Galla, T. Budde, H. Wiendl, S.G. Meuth
Nat. Med. 19, 1161 (2013).
CD4+NKG2D+ T Cells Exhibit Enhanced Migratory and Encephalitogenic Properties in Neuroinflammation
T. Ruck, S. Bittner, C.C. Gross, J. Breuer, S. Albrecht, S. Korr, K. Göbel, S. Pankratz, C.M. Henschel, N. Schwab, O. Staszewski, M. Prinz, T. Kuhlmann, S.G. Meuth, H. Wiendl
PLoS ONE 8, e70225 (2013).
Curcumin Prevents Replication of Respiratory Syncytial Virus and the Epithelial Responses to It in Human Nasal Epithelial Cells
K. Obata, T. Kojima, T. Masaki, T. Okabayashi, S. Yokota, S. Hirakawa, K. Nomura, A. Takasawa, M. Murata, S. Tanaka, J. Fuchimoto, N. Fujii, H. Tsutsumi, T. Himi, N. Sawada
PLoS ONE 8, e70225 (2013).
Influence of T-2 and HT-2 Toxin on the Blood-Brain Barrier In Vitro: New Experimental Hints for Neurotoxic Effects.
M. Weidner, S. Hüwel, F. Ebert, T. Schwerdtle, H.J. Galla, H.U. Humpf
PLoS ONE 8, e60484 (2013).
Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier In Vitro
R. Paolinelli, M. Corada, L. Ferrarini, K. Devraj, C. Artus, C.J. Czupalla, N. Rudini, L. Maddaluno, E. Papa, B. Engelhardt, P.O. Couraud, S. Liebner, E. Dejana
PLoS One 8, e70233 (2013).
2012
Receptor-Mediated Delivery of Magnetic Nanoparticles across the Blood–Brain Barrier
R. Qiao, Q. Jia, S. Hüwel, R. Xia, T. Liu, F. Gao, H.J. Galla, M. Gao
ACS Nano 6, 3304 (2012).
Differential Targeting of the E-Cadherin/ß-Catenin Complex by Gram-positive Probiotic Lactobacilli Improves Epithelial Barrier Function
S. Hummel, K. Veltman, C. Cichon, U. Sonnenborn, M.A. Schmidt
Appl. Environ. Microbiol. 78, 1140 (2012).
Inhibitory effect of phospholipids on P-glycoprotein: Cellular studies in Caco-2, MDCKII mdr1 and MDCKII wildtype cells and P-gp ATPase activity measurements
S. Simon, R. Schubert
Biochim. Biophys. Acta 1821, 1211 (2012).
Streptococcus pneumoniae induces exocytosis of Weibel-Palade bodies in pulmonary endothelial cells
M. Lüttge, M. Fulde, S.R. Talay, A. Nerlich, M. Rohde, K.T. Preissner, S. Hammerschmidt, M. Steinert, T.J. Mitchell, G.S. Chhatwal, S. Bergmann
Cell. Microbiol. 14, 210 (2012).
Impact of FaSSIF on the solubility and dissolution-/permeation rate of a poorly water-soluble compound
K. J. Frank, U. Westedt, K. M. Rosenblatt, P. Hölig, J. Rosenberg, M. Mägerlein, M. Brandl, G. Fricker
Euro. J. Pharm. Sci. 47, 16 (2012).
Identification of specific miRNAs targeting proteins of the apical junctional complex that simulate the probiotic effect of E. coli Nissle 1917 on T84 epithelial cells
K. Veltman, S. Hummel, C. Cichon, U. Sonnenborn, M.A. Schmidt
Int. J. Biochem. Cell Biol. 44, 341 (2012).
Amorphous solid dispersion enhances permeation of poorly soluble ABT-102: True supersaturation vs. apparent solubility enhancement
K.J. Frank, K.M. Rosenblatt, U. Westedt, P. Hölig, J. Rosenberg, M. Mägerlein, G. Fricker, M. Brandl
Int. J. Pharm. 437, 288 (2012).
Impact of manganese on and transfer across the blood-brain and blood-CSF barrier in vitro
J. Bornhorst, C.A. Wehe, S. Hüwel, U. Karst, H.J. Galla, T. Schwerdtle
J. Biol. Chem. 287, 17140 (2012).
Mechanism of Clostridium perfringens Enterotoxin Interaction with Claudin-3/-4 Protein Suggests Structural Modifications of the Toxin to Target Specific Claudins
A. Veshnyakova, J. Piontek, J. Protze, N. Waziri, I. Heise, G. Krause
J. Biol. Chem. 287, 1698 (2012).
aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation
S. Iden, S. Misselwitz, S.S.D. Peddibhotla, H. Tuncay, D. Rehder, V. Gerke, H. Robenek, A. Suzuki, K. Ebnet
J. Cell. Biol. 196, 623 (2012).
Preparation and properties of nanoscale containers for biomedical application in drug delivery: preliminary studies with kynurenic acid
V. Hornok, T. Bujdosó, J. Toldi, K. Nagy, I. Demeter, C. Fazakas, I. Krizbai, L. Vécsei, I. Dékány
J. Neural. Transm. 119, 115 (2012).
Cellular Interactions of a Water-Soluble Supramolecular Polymer Complex of Carbon Nanotubes with Human Epithelial Colorectal Adenocarcinoma Cells
Y. Lee, K. E. Geckeler
Macro. Biosci. 12, 1060 (2012).
Permeability of ergot alkaloids across the blood–brain barrier in vitro and influence on the barrier integrity
D. Mulac, S. Hüwel, H.J. Galla, H.U. Humpf
Mol. Nutr. Food Res. 56, 475 (2012).
2011
In vitro models of the blood-brain barrier
I. Wilhelm, C. Fazakas, I. A. Krizbai
Acta Neurobiol. Exp. 71, 113 (2011).
Transport of Poly(n-butylcyano-acrylate) nanoparticles across the blood–brain barrier in vitro and their influence on barrier integrity
R. Rempe, S. Cramer, H.J. Galla
Biochem. Biophys. Res. Commun. 406, 64 (2011).
Neutrophils cross the BBB primarily on transcellular pathways: An in vitro study
M. von Wedel-Parlow, S. Schrot, J. Lemmen, L. Treeratanapiboon, J. Wegener, H.J. Galla
Brain Res. 1367, 62 (2011).
The impact of pericytes on the blood–brain barrier integrity depends critically on the pericyte differentiation stage
G. Thanabalasundaram, J. Schneidewind, C. Pieper, H.J. Galla
Int. J. Biochem. Cell Biol. 43, 1284 (2011). → doi: 10.1016/j.biocel.2011.05.002
Transport of Arylsulfatase A across the Blood-Brain Barrier in Vitro
F. Matthes, P. Wölte, A. Böckenhoff, S. Hüwel, M. Schulz, P. Hyden, J. Fogh, V. Gieselmann, H.J. Galla, U.Matzner
J. Biol. Chem. 286, 17487 (2011).
Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo
M. Schnoor, F.P.L. Lai, A. Zarbock, R. Kläver, C. Polaschegg, D. Schulte, H.A. Weich, J.M. Oelkers, K. Rottner, D. Vestweber
J. Exp. Med. 208, 1721 (2011).
Interactions of the prion peptide (PrP 106–126) with brain capillary endothelial cells: coordinated cell killing and remodeling of intercellular junctions
I. Cooper, K.C.-K. Malina, A. Cagnotto, G. Bazzoni, M. Salmona, V.I. Teichberg
J. Neurochem. 116, 467 (2011).
Effect of the non-ionic surfactant Poloxamer 188 on passive permeability of poorly soluble drugs across Caco-2 cell monolayers
S.M. Fischer, M. Brandl, G. Fricker
J. Pharm. Biopharm. 79, 416 (2011).
Transmigration of Melanoma Cells through the Blood-Brain Barrier: Role of Endothelial Tight Junctions and Melanoma-Released Serine Proteases
C. Fazakas, I. Wilhelm, P. Nagyöszi, A.E. Farkas, J. Hasko, J. Molnar, H. Bauer, H.C. Bauer, F. Ayaydin, N.T.K. Dung, L. Siklos, I.A. Krizbai
PLoS ONE 6, e20758 (2011).
HI 6 human serum albumin nanoparticles - Development and transport over an in vitro blood-brain barrier model
M. Dadparvara, S. Wagner, S. Wien, J. Kufleitner, F. Worek, H. von Briesen, J. Kreutera
Tox. Lett. 206, 60 (2011).
2010
Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier
J. Karczewski, F.J. Troost, I. Konings, J. Dekker, M. Kleerebezem, R.-J.M. Brummer, J.M. Wells
Am. J. Physiol. Gastrointest. Liver Physiol. 298, G851 (2010). → doi: 10.1152/ajpgi.00327.2009
In vitro-Testverfahren zur Toxikologie von Nanomaterialien
A. Kroll, D. Hahn, J. Schnekenburger
BIOspectrum 16, 48 (2010).
Metalloproteinase mediated occludin cleavage in the cerebral microcapillary endothelium under pathological conditions
M. Lischper, S. Beuck, G. Thanabalasundaram, C. Pieper, H.J. Galla
Brain Res. 1326, 114 (2010).
Regulation of the blood-brain barrier integrity by pericytes via matrix metalloproteinases mediated activation of vascular endothelial growth factor in vitro
G. Thanabalasundaram, C. Pieper, M. Lischper, H.J. Galla
Brain Res. 1347, 1 (2010). → doi: 10.1016/j.brainres.2010.05.096
Characterization of immortalized choroid plexus epithelial cell lines for studies of transport processes across the blood-cerebrospinal fluid barrier
J. Kläs, H. Wolburg, T. Terasaki, G. Fricker, V. Reichel
Cerebrospinal Fluid Res. 7, 11 (2010).
In vitro evaluation of liposomes containing bio-enhancers for the oral delivery of macromolecules
J. Parmentier, F.J. Hartmann, G. Fricker
Euro. J. Pharm. Biopharm. 76, 394 (2010).
Epithelial Barrier Resistance is Increased by the Divalent Cation Zinc in Cultured MDCKII Epithelial Monolayers
G. Carr, J.A. Wright, N.L. Simmons
J. Membr. Biol. 237, 115 (2010).
Functionalized gold nanoparticles: a detailed in vivo multimodal microscopic brain distribution study
F. Sousa, S. Mandal,C. Garrovo, A. Astolfo, A. Bonifacio, D. Latawiec,R.H. Menk, F. Arfelli, S. Hüwel, G. Legname, H.J. Galla, S. Krol
Nanoscale 2, 2826 (2010).
Nanoparticulate Transport of Oximes over an In Vitro Blood-Brain Barrier Model
S. Wagner, J. Kufleitner, A. Zensi, M. Dadparvar, S. Wien, J. Bungert, T. Vogel, F. Worek, J. Kreuter, H. von Briesen
PLoS ONE 5, e14213 (2010).
2009
Control of the blood-brain barrier by glucocorticoids and the cells of the neurovascular unit
S. Kröll, J. El-Gindi, G. Thanabalasundaram, P. Panpumthong, S. Schrot, C. Hartmann, H.J. Galla
Ann. N.Y. Acad. Sci. 1165, 228 (2009).
Closing the gap between the in-vivo and in-vitro blood–brain barrier tightness
K.C.-K. Malina, I. Cooper, V.I. Teichberg
Brain Res. 1284, 12 (2009).
Regulation of major efflux transporters under inflammatory conditions at the blood brain barrier in vitro
M. von Wedel-Parlow, P. Wölte, H.J. Galla
J. Neurochem. 111, 111 (2009).